Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171263
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DC Field | Value | Language |
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dc.contributor.author | Jiang, Xia | - |
dc.contributor.author | Finucane, Hilary K. | - |
dc.contributor.author | Schumacher, Fredrick R. | - |
dc.contributor.author | Schmit, Stephanie L. | - |
dc.contributor.author | Tyrer, Jonathan P. | - |
dc.contributor.author | Han, Younghun | - |
dc.contributor.author | Michailidou, Kyriaki | - |
dc.contributor.author | Lesseur, Corina | - |
dc.contributor.author | Kuchenbaecker, Karoline B. | - |
dc.contributor.author | Dennis, Joe | - |
dc.contributor.author | Conti, David V. | - |
dc.contributor.author | deFazio, Anna | - |
dc.contributor.author | Czene, Kamila | - |
dc.contributor.author | Ganz, Patricia A. | - |
dc.contributor.author | Campa, Daniele | - |
dc.contributor.author | Lindström, Sara | - |
dc.contributor.author | Franceschi, Silvia | - |
dc.contributor.author | Ziogas, Argyrios | - |
dc.contributor.author | Plaseska-Karanfilska, Dijana | - |
dc.contributor.author | Gago-Dominguez, Manuela | - |
dc.contributor.author | Edlund, Christopher K. | - |
dc.contributor.author | Neal, David E. | - |
dc.contributor.author | Shen, Hongbing | - |
dc.contributor.author | Blomqvist, Carl | - |
dc.contributor.author | Hillemanns, Peter | - |
dc.contributor.author | Travis, Ruth C. | - |
dc.contributor.author | Sundfeldt, Karin | - |
dc.contributor.author | Lester, Jenny | - |
dc.contributor.author | Dwek, Miriam | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Grankvist, Kjell | - |
dc.contributor.author | Setiawan, V. Wendy | - |
dc.contributor.author | Pandha, Hardev | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Brook, Mark N. | - |
dc.contributor.author | Rennert, Hedy S. | - |
dc.contributor.author | Lindo, Noralane M. | - |
dc.contributor.author | Lam, Stephan | - |
dc.contributor.author | Teare, M. Dawn | - |
dc.contributor.author | Sandler, Dale P. | - |
dc.contributor.author | van Rensburg, Elizabeth J. | - |
dc.contributor.author | Levine, Douglas A. | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Sorensen, Karina Dalsgaard | - |
dc.contributor.author | Sutphen, Rebecca | - |
dc.contributor.author | Miller, Austin | - |
dc.contributor.author | Isaacs, Claudine | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Campbell, Peter T. | - |
dc.contributor.author | Olshan, Andrew F. | - |
dc.contributor.author | Modugno, Francesmary | - |
dc.contributor.author | Ramu, Susan J. | - |
dc.contributor.author | James, Paul | - |
dc.contributor.author | Cox, Angela | - |
dc.contributor.author | Caldés, Trinidad | - |
dc.contributor.author | Wang, Qin | - |
dc.contributor.author | Simard, Jacques | - |
dc.contributor.author | Pasaniuc, Bogdan | - |
dc.contributor.author | Carvalho, André L. | - |
dc.contributor.author | Lambrechts, Diether | - |
dc.contributor.author | Antonenkova, Natalia N. | - |
dc.contributor.author | Andrew, Angeline S. | - |
dc.contributor.author | Johansson, Mikael | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Herrero, Rolando | - |
dc.contributor.author | Boccia, Stefania | - |
dc.contributor.author | Håkansson, Niclas | - |
dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Lejbkowicz, Flavio | - |
dc.contributor.author | Pharoah, Paul D. P. | - |
dc.contributor.author | Hamilton, Robert J. | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Gruber, Stephen B. | - |
dc.contributor.author | Gronberg, Henrik | - |
dc.contributor.author | Kristensen, Vessela N. | - |
dc.contributor.author | Sieh, Weiva | - |
dc.contributor.author | Saxena, Richa | - |
dc.contributor.author | Joshi, Amit D. | - |
dc.contributor.author | Olah, Edith | - |
dc.contributor.author | Zienolddiny, Shanbeh | - |
dc.contributor.author | Vega, Ana | - |
dc.contributor.author | Gayther, Simon A. | - |
dc.contributor.author | Campbell, Ian | - |
dc.contributor.author | Kühl, Tabea | - |
dc.contributor.author | Hall, Per | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Dunning, Alison M. | - |
dc.contributor.author | Stintzing, Sebastian | - |
dc.contributor.author | Osorio, Ana | - |
dc.contributor.author | Hoffmeister, Michael | - |
dc.contributor.author | Spurdle, Amanda B. | - |
dc.contributor.author | Marchand, Loïc Le | - |
dc.contributor.author | Buchanan, Daniel D. | - |
dc.contributor.author | Slattery, Martha L. | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Kelemen, Linda E. | - |
dc.contributor.author | Fortner, Renée T. | - |
dc.contributor.author | Weinstein, Stephanie | - |
dc.contributor.author | Penney, Kathryn L. | - |
dc.contributor.author | Jenkins, Mattias | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Kupryjanczyk, Jolanta | - |
dc.contributor.author | Kibel, Adam S. | - |
dc.contributor.author | Weissler, Mark C. | - |
dc.contributor.author | Torres, Diana | - |
dc.contributor.author | Terry, Kathryn L. | - |
dc.contributor.author | Ness, Andrew R. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Chan, Andrew T. | - |
dc.contributor.author | Christiani, David C. | - |
dc.contributor.author | Liu, Geoffrey | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Barnes, Daniel R. | - |
dc.contributor.author | Muir, Kenneth | - |
dc.contributor.author | West, Catharine M. L. | - |
dc.contributor.author | Lesse, Davor | - |
dc.contributor.author | Schabath, Matthew B. | - |
dc.contributor.author | Kjaer, Susanne K. | - |
dc.contributor.author | Bickeböller, Heike | - |
dc.contributor.author | Mulligan, Anna Marie | - |
dc.contributor.author | Mucci, Lorelei | - |
dc.contributor.author | Jakubowska, Anna | - |
dc.contributor.author | Nikitina-Zake, Liene | - |
dc.contributor.author | Loupakis, Fotios | - |
dc.contributor.author | Van Nieuwenhuysen, Els | - |
dc.contributor.author | Wu, Anna H. | - |
dc.contributor.author | Pashayan, Nora | - |
dc.contributor.author | Risch, Angela | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Maier, Christiane | - |
dc.contributor.author | Wu, Xifeng | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Southey, Melissa C. | - |
dc.contributor.author | Townsend, Paul A. | - |
dc.contributor.author | Thomas, Duncan | - |
dc.contributor.author | Vachon, Celine M. | - |
dc.contributor.author | Eccles, Diana | - |
dc.contributor.author | Schmidt, Marjanka K. | - |
dc.contributor.author | Kote-Jarai, Zsofia | - |
dc.contributor.author | Huyghe, Jeroen R. | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Claessens, Frank | - |
dc.contributor.author | May, Taymaa | - |
dc.contributor.author | Houlston, Richard | - |
dc.contributor.author | Fasching, Peter A. | - |
dc.contributor.author | Kim, Jeri | - |
dc.contributor.author | Prokofyeva, Darya | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Antoniou, Antonis C. | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | Kiemeney, Lambertus A. | - |
dc.contributor.author | Eeles, Rosalind A. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Bogdanova, Natalia V. | - |
dc.contributor.author | Guénel, Pascal | - |
dc.contributor.author | Gronwald, Jacek | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Batra, Jyotsna | - |
dc.contributor.author | Lindblom, Annika | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Leslie, Goska | - |
dc.contributor.author | Thomassen, Mads | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Nussbaum, Robert L. | - |
dc.contributor.author | Benlloch, Sara | - |
dc.contributor.author | Al Olama, Ali Amin | - |
dc.contributor.author | Pring, Miranda | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Cancel-Tassin, Géraldine | - |
dc.contributor.author | Price, Alkes L. | - |
dc.contributor.author | Woods, Michael | - |
dc.contributor.author | Tworoger, Shelley S. | - |
dc.contributor.author | Nathanson, Katherine L. | - |
dc.contributor.author | Ellberg, Carolina | - |
dc.contributor.author | Teixeira, Manuel R. | - |
dc.contributor.author | Saloustros, Emmanouil | - |
dc.contributor.author | Tischkowitz, Marc | - |
dc.contributor.author | Zorn, Kristin K. | - |
dc.contributor.author | Newcomb, Polly A. | - |
dc.contributor.author | Cunningham, Julie M. | - |
dc.contributor.author | John, Esther M. | - |
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Bolla, Manjeet K. | - |
dc.contributor.author | Casey, Graham | - |
dc.contributor.author | Margolin, Sara | - |
dc.contributor.author | Goodman, Gary | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | Riggan, Marjorie J. | - |
dc.contributor.author | Fostira, Florentia | - |
dc.contributor.author | Kaneva, Radka | - |
dc.contributor.author | Arnold, Susanne M. | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Ruyck, Kim De | - |
dc.contributor.author | Olsson, Håkan | - |
dc.contributor.author | Arun, Banu K. | - |
dc.contributor.author | Schleutker, Johanna | - |
dc.contributor.author | Aronson, Kristan J. | - |
dc.contributor.author | Caligo, Maria A. | - |
dc.contributor.author | Ingles, Sue Ann | - |
dc.contributor.author | Hsu, Li | - |
dc.contributor.author | Rosenstein, Barry S. | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | McKay, James D. | - |
dc.contributor.author | Claes, Kathleen B. M. | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Nordestgaard, Børge G. | - |
dc.contributor.author | Park, Jong Y. | - |
dc.contributor.author | Cadoni, Gabriella | - |
dc.contributor.author | Diez, Orland | - |
dc.contributor.author | Ferris, Robert L. | - |
dc.contributor.author | Stefansson, Kari | - |
dc.contributor.author | Cannon-Albright, Lisa A. | - |
dc.contributor.author | Weinberg, Clarice R. | - |
dc.contributor.author | McGuffog, Lesley | - |
dc.contributor.author | Raskin, Leon | - |
dc.contributor.author | Mannermaa, Arto | - |
dc.contributor.author | Neuhausen, Susan L. | - |
dc.contributor.author | Hulick, Peter J. | - |
dc.contributor.author | Wichmann, H-Erich | - |
dc.contributor.author | Goldberg, Mark S. | - |
dc.contributor.author | Greene, Mark H. | - |
dc.contributor.author | Maehle, Lovise | - |
dc.contributor.author | Yannoukakos, Drakoulis | - |
dc.contributor.author | Garber, Judy | - |
dc.contributor.author | Webb, Penelope M. | - |
dc.contributor.author | Pejovic, Tanja | - |
dc.contributor.author | Bojesen, Stig E. | - |
dc.contributor.author | Toland, Amanda E. | - |
dc.contributor.author | Knight, Julia A. | - |
dc.contributor.author | Huntsman, David G. | - |
dc.contributor.author | Dörk, Thilo | - |
dc.contributor.author | Gaudet, Mia M. | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Whittemore, Alice S. | - |
dc.contributor.author | Hung, Rayjean J. | - |
dc.contributor.author | García-Closas, Montserrat | - |
dc.contributor.author | Li, Li | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Haugen, Aage | - |
dc.contributor.author | Cruz Correa, Marcia | - |
dc.contributor.author | Wolk, Alicja | - |
dc.contributor.author | Olopade, Olufunmilayo I. | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Hamdy, Freddie C. | - |
dc.contributor.author | Burwinkel, Barbara | - |
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dc.contributor.author | Parsons, Michael T. | - |
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dc.contributor.author | Middha, Pooja | - |
dc.contributor.author | Terry, Mary Beth | - |
dc.contributor.author | Newcomb, Lisa F. | - |
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dc.contributor.author | Montagna, Marco | - |
dc.contributor.author | Brenton, James D. | - |
dc.contributor.author | Roobol, Monique J. | - |
dc.contributor.author | Thibodeau, Stephen N. | - |
dc.contributor.author | Hampe, Jochen | - |
dc.contributor.author | Lubiński, Jan | - |
dc.contributor.author | Tung, Nadine | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Stone, Jennifer | - |
dc.contributor.author | Swerdlow, Anthony J. | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Wiklund, Fredrik | - |
dc.contributor.author | Bandera, Elisa V. | - |
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dc.contributor.author | Donovan, Jenny L. | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Aldrich, Melinda C. | - |
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dc.contributor.author | Heitz, Florian | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Peters, Ulrike | - |
dc.contributor.author | Albanes, Jeroen R. | - |
dc.contributor.author | Singer, Christian F. | - |
dc.contributor.author | Woll, Penella | - |
dc.contributor.author | Tajara, Eloiza H. | - |
dc.contributor.author | Weitzel, Jeffrey N. | - |
dc.contributor.author | García-Sáenz, José A. | - |
dc.contributor.author | Liloglou, Triantafillos | - |
dc.contributor.author | Phipps, Amanda I. | - |
dc.contributor.author | Cybulski, Cezary | - |
dc.contributor.author | Li, Christopher I. | - |
dc.contributor.author | Lazarus, Philip | - |
dc.contributor.author | Sawyer, Elinor J. | - |
dc.contributor.author | Lane, Jacqueline M. | - |
dc.contributor.author | Meindl, Alfons | - |
dc.contributor.author | Peters, Wilbert H. M. | - |
dc.contributor.author | Goode, Ellen L. | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Butzow, Ralf | - |
dc.contributor.author | Barkardottir, Rosa B. | - |
dc.contributor.author | Bien, Stephanie A. | - |
dc.contributor.author | Ulrich, Cornelia M. | - |
dc.contributor.author | Brunnström, Hans | - |
dc.contributor.author | Goldgar, David E. | - |
dc.contributor.author | Koutros, Stella | - |
dc.contributor.author | Fletcher, Olivia | - |
dc.contributor.author | Moysich, Kirsten B. | - |
dc.contributor.author | Høgdall, Estrid | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Lacko, Martin | - |
dc.contributor.author | Chen, Chu | - |
dc.contributor.author | Beckmann, Matthias W. | - |
dc.contributor.author | Elías Aguado-Barrera, Miguel | - |
dc.contributor.author | Imyanitov, Evgeny N. | - |
dc.contributor.author | Clements, Judith | - |
dc.contributor.author | Lenz, Heinz-Josef | - |
dc.contributor.author | MacInnis, Robert J. | - |
dc.contributor.author | Idos, Gregory | - |
dc.contributor.author | Daly, Mary B. | - |
dc.contributor.author | Anton-Culver, Hoda | - |
dc.contributor.author | Winqvist, Robert | - |
dc.contributor.author | Khusnutdinova, Elza | - |
dc.contributor.author | Diergaarde, Brenda | - |
dc.contributor.author | Collée, J. Margriet | - |
dc.contributor.author | Rossing, Mary Anne | - |
dc.contributor.author | Bjørge, Line | - |
dc.contributor.author | Phelan, Catherine M. | - |
dc.contributor.author | Usmani, Nawaid | - |
dc.date.accessioned | 2020-10-15T11:17:47Z | - |
dc.date.available | 2020-10-15T11:17:47Z | - |
dc.date.issued | 2019-01-25 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171263 | - |
dc.description.abstract | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. | - |
dc.format.extent | 23 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4 | - |
dc.relation.ispartof | Nature Communications, 2019, vol. 10, p. 431 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-018-08054-4 | - |
dc.rights | cc-by (c) Jiang et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Etiologia | - |
dc.subject.other | Cancer | - |
dc.subject.other | Etiology | - |
dc.title | Shared heritability and functional enrichment across six solid cancers | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 698689 | - |
dc.date.updated | 2020-10-15T11:17:47Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/633784/EU//B-CAST | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/223175/EU//COGS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/669026/EU//BIORISE | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/634935/EU//BRIDGES | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30683880 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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698689.pdf | 3.83 MB | Adobe PDF | View/Open |
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