Title: | Shared heritability and functional enrichment across six solid cancers |
Author: | Jiang, Xia Finucane, Hilary K. Schumacher, Fredrick R. Schmit, Stephanie L. Tyrer, Jonathan P. Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B. Dennis, Joe Conti, David V. deFazio, Anna Czene, Kamila Ganz, Patricia A. Campa, Daniele Lindström, Sara Franceschi, Silvia Ziogas, Argyrios Plaseska-Karanfilska, Dijana Gago-Dominguez, Manuela Edlund, Christopher K. Neal, David E. Shen, Hongbing Blomqvist, Carl Hillemanns, Peter Travis, Ruth C. Sundfeldt, Karin Lester, Jenny Dwek, Miriam Brunet, Joan Grankvist, Kjell Setiawan, V. Wendy Pandha, Hardev Radice, Paolo Brook, Mark N. Rennert, Hedy S. Lindo, Noralane M. Lam, Stephan Teare, M. Dawn Sandler, Dale P. van Rensburg, Elizabeth J. Levine, Douglas A. Milne, Roger L. Sorensen, Karina Dalsgaard Sutphen, Rebecca Miller, Austin Isaacs, Claudine Zheng, Wei Campbell, Peter T. Olshan, Andrew F. Modugno, Francesmary Ramu, Susan J. James, Paul Cox, Angela Caldés, Trinidad Wang, Qin Simard, Jacques Pasaniuc, Bogdan Carvalho, André L. Lambrechts, Diether Antonenkova, Natalia N. Andrew, Angeline S. Johansson, Mikael Johansson, Mattias Herrero, Rolando Boccia, Stefania Håkansson, Niclas Berndt, Sonja I. Lejbkowicz, Flavio Pharoah, Paul D. P. Hamilton, Robert J. Moreno Aguado, Víctor Gruber, Stephen B. Gronberg, Henrik Kristensen, Vessela N. Sieh, Weiva Saxena, Richa Joshi, Amit D. Olah, Edith Zienolddiny, Shanbeh Vega, Ana Gayther, Simon A. Campbell, Ian Kühl, Tabea Hall, Per Rennert, Gad Dunning, Alison M. Stintzing, Sebastian Osorio, Ana Hoffmeister, Michael Spurdle, Amanda B. Marchand, Loïc Le Buchanan, Daniel D. Slattery, Martha L. Hamann, Ute Caporaso, Neil E. Kelemen, Linda E. Fortner, Renée T. Weinstein, Stephanie Penney, Kathryn L. Jenkins, Mattias Tardón, Adonina Kupryjanczyk, Jolanta Kibel, Adam S. Weissler, Mark C. Torres, Diana Terry, Kathryn L. Ness, Andrew R. Nevanlinna, Heli Chan, Andrew T. Christiani, David C. Liu, Geoffrey Lee, Eunjung Barnes, Daniel R. Muir, Kenneth West, Catharine M. L. Lesse, Davor Schabath, Matthew B. Kjaer, Susanne K. Bickeböller, Heike Mulligan, Anna Marie Mucci, Lorelei Jakubowska, Anna Nikitina-Zake, Liene Loupakis, Fotios Van Nieuwenhuysen, Els Wu, Anna H. Pashayan, Nora Risch, Angela Andrulis, Irene L. Maier, Christiane Wu, Xifeng Khaw, Kay-Tee Southey, Melissa C. Townsend, Paul A. Thomas, Duncan Vachon, Celine M. Eccles, Diana Schmidt, Marjanka K. Kote-Jarai, Zsofia Huyghe, Jeroen R. Duell, Eric J. Claessens, Frank May, Taymaa Houlston, Richard Fasching, Peter A. Kim, Jeri Prokofyeva, Darya Giles, Graham G. Karlan, Beth Y. Antoniou, Antonis C. Figueiredo, Jane C. Kiemeney, Lambertus A. Eeles, Rosalind A. Kogevinas, Manolis Bogdanova, Natalia V. Guénel, Pascal Gronwald, Jacek Brennan, Paul Batra, Jyotsna Lindblom, Annika Amos, Christopher I. Leslie, Goska Thomassen, Mads Haiman, Christopher A. Nussbaum, Robert L. Benlloch, Sara Al Olama, Ali Amin Pring, Miranda Benitez, Javier Cancel-Tassin, Géraldine Price, Alkes L. Woods, Michael Tworoger, Shelley S. Nathanson, Katherine L. Ellberg, Carolina Teixeira, Manuel R. Saloustros, Emmanouil Tischkowitz, Marc Zorn, Kristin K. Newcomb, Polly A. Cunningham, Julie M. John, Esther M. Couch, Fergus J. Bolla, Manjeet K. Casey, Graham Margolin, Sara Goodman, Gary Evans, D. Gareth Riggan, Marjorie J. Fostira, Florentia Kaneva, Radka Arnold, Susanne M. Offit, Kenneth Ruyck, Kim De Olsson, Håkan Arun, Banu K. Schleutker, Johanna Aronson, Kristan J. Caligo, Maria A. Ingles, Sue Ann Hsu, Li Rosenstein, Barry S. Chenevix-Trench, Georgia McKay, James D. Claes, Kathleen B. M. Chanock, Stephen J. Nordestgaard, Børge G. Park, Jong Y. Cadoni, Gabriella Diez, Orland Ferris, Robert L. Stefansson, Kari Cannon-Albright, Lisa A. Weinberg, Clarice R. McGuffog, Lesley Raskin, Leon Mannermaa, Arto Neuhausen, Susan L. Hulick, Peter J. Wichmann, H-Erich Goldberg, Mark S. Greene, Mark H. Maehle, Lovise Yannoukakos, Drakoulis Garber, Judy Webb, Penelope M. Pejovic, Tanja Bojesen, Stig E. Toland, Amanda E. Knight, Julia A. Huntsman, David G. Dörk, Thilo Gaudet, Mia M. Hong, Yun-Chul Whittemore, Alice S. Hung, Rayjean J. García-Closas, Montserrat Li, Li Friedman, Eitan Haugen, Aage Cruz Correa, Marcia Wolk, Alicja Olopade, Olufunmilayo I. Risch, Harvey A. Hamdy, Freddie C. Burwinkel, Barbara Brauch, Hiltrud Parsons, Michael T. Tangen, Catherine M. Middha, Pooja Terry, Mary Beth Newcomb, Lisa F. Nielsen, Finn C. Stanford, Janet L. Kraft, Peter Montagna, Marco Brenton, James D. Roobol, Monique J. Thibodeau, Stephen N. Hampe, Jochen Lubiński, Jan Tung, Nadine Chang-Claude, Jenny Stone, Jennifer Swerdlow, Anthony J. Brenner, Hermann Wiklund, Fredrik Bandera, Elisa V. Siegel, Erin M. Le, Nhu D. Taylor, Jack A. Donovan, Jenny L. Landi, Maria Teresa Aldrich, Melinda C. White, Emily Stevens, Victoria L. Velez Edwards, Digna R. Goodman, Marc T. Easton, Douglas F. Berchuck, Andrew Devilee, Peter Heitz, Florian Hopper, John L. Hunter, David J. Peters, Ulrike Albanes, Jeroen R. Singer, Christian F. Woll, Penella Tajara, Eloiza H. Weitzel, Jeffrey N. García-Sáenz, José A. Liloglou, Triantafillos Phipps, Amanda I. Cybulski, Cezary Li, Christopher I. Lazarus, Philip Sawyer, Elinor J. Lane, Jacqueline M. Meindl, Alfons Peters, Wilbert H. M. Goode, Ellen L. Godwin, Andrew K. Butzow, Ralf Barkardottir, Rosa B. Bien, Stephanie A. Ulrich, Cornelia M. Brunnström, Hans Goldgar, David E. Koutros, Stella Fletcher, Olivia Moysich, Kirsten B. Høgdall, Estrid Gallinger, Steven Lacko, Martin Chen, Chu Beckmann, Matthias W. Elías Aguado-Barrera, Miguel Imyanitov, Evgeny N. Clements, Judith Lenz, Heinz-Josef MacInnis, Robert J. Idos, Gregory Daly, Mary B. Anton-Culver, Hoda Winqvist, Robert Khusnutdinova, Elza Diergaarde, Brenda Collée, J. Margriet Rossing, Mary Anne Bjørge, Line Phelan, Catherine M. Usmani, Nawaid |
Keywords: | Càncer Etiologia Cancer Etiology |
Issue Date: | 25-Jan-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4 |
It is part of: | Nature Communications, 2019, vol. 10, p. 431 |
URI: | http://hdl.handle.net/2445/171263 |
Related resource: | https://doi.org/10.1038/s41467-018-08054-4 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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