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http://hdl.handle.net/2445/171400
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DC Field | Value | Language |
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dc.contributor.author | Villar Piqué, Anna | - |
dc.contributor.author | Schmitz, Matthias | - |
dc.contributor.author | Hermann, Peter | - |
dc.contributor.author | Goebel, Stefan | - |
dc.contributor.author | Bunck, Timothy | - |
dc.contributor.author | Varges, Daniela | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.contributor.author | Riggert, Joachim | - |
dc.contributor.author | Llorens Torres, Franc | - |
dc.contributor.author | Zerr, Inga | - |
dc.date.accessioned | 2020-10-22T13:54:37Z | - |
dc.date.available | 2020-10-22T13:54:37Z | - |
dc.date.issued | 2019-07-12 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171400 | - |
dc.description.abstract | Background: Increased plasma YKL-40 has been reported in Alzheimer's disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias. Methods: YKL-40 was quantified in the plasma of 315 cases, including healthy controls (HC), neurological disease controls (ND), AD, vascular dementia (VaD), frontotemporal dementia (FTD), sporadic Creutzfeldt-Jakob disease (CJD) and Lewy body dementia (LBD). Diagnostic accuracy in the differential diagnostic context and influence of age and gender was assessed. Results: Highest YKL-40 levels were detected in CJD, followed by LBD, VaD, AD, FTD, ND and HC. YKL-40 was associated to age but not to sex. After controlling for age, YKL-40 was significantly elevated in CJD compared to HC (p<0.001), ND, AD and VaD (p<0.01) and in LBD compared to HC (p<0.05). In CJD, YKL-40 concentrations were significantly higher at late disease stages. Conclusions: Plasma YKL-40 is significantly elevated in CJD regardless of clinical and genetic parameters, with moderate diagnostic accuracy in the discrimination from control cases. Our study discards a potential use of this biomarker in the differential diagnostic context but opens the possibility to be explored as a marker for CJD monitoring. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12974-019-1531-3 | - |
dc.relation.ispartof | Journal of Neuroinflammation, 2019, vol. 16 | - |
dc.relation.uri | https://doi.org/10.1186/s12974-019-1531-3 | - |
dc.rights | cc by (c) Villar Piqué et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Demència | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.other | Dementia | - |
dc.subject.other | Alzheimer's disease | - |
dc.title | Plasma YKL-40 in the spectrum of neurodegenerative dementia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-10-13T10:25:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31299989 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Villar-PiqueA.pdf | 530.9 kB | Adobe PDF | View/Open |
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