Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171400
Title: | Plasma YKL-40 in the spectrum of neurodegenerative dementia |
Author: | Villar Piqué, Anna Schmitz, Matthias Hermann, Peter Goebel, Stefan Bunck, Timothy Varges, Daniela Ferrer, Isidro (Ferrer Abizanda) Riggert, Joachim Llorens Torres, Franc Zerr, Inga |
Keywords: | Demència Malaltia d'Alzheimer Dementia Alzheimer's disease |
Issue Date: | 12-Jul-2019 |
Publisher: | BioMed Central |
Abstract: | Background: Increased plasma YKL-40 has been reported in Alzheimer's disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias. Methods: YKL-40 was quantified in the plasma of 315 cases, including healthy controls (HC), neurological disease controls (ND), AD, vascular dementia (VaD), frontotemporal dementia (FTD), sporadic Creutzfeldt-Jakob disease (CJD) and Lewy body dementia (LBD). Diagnostic accuracy in the differential diagnostic context and influence of age and gender was assessed. Results: Highest YKL-40 levels were detected in CJD, followed by LBD, VaD, AD, FTD, ND and HC. YKL-40 was associated to age but not to sex. After controlling for age, YKL-40 was significantly elevated in CJD compared to HC (p<0.001), ND, AD and VaD (p<0.01) and in LBD compared to HC (p<0.05). In CJD, YKL-40 concentrations were significantly higher at late disease stages. Conclusions: Plasma YKL-40 is significantly elevated in CJD regardless of clinical and genetic parameters, with moderate diagnostic accuracy in the discrimination from control cases. Our study discards a potential use of this biomarker in the differential diagnostic context but opens the possibility to be explored as a marker for CJD monitoring. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12974-019-1531-3 |
It is part of: | Journal of Neuroinflammation, 2019, vol. 16 |
URI: | http://hdl.handle.net/2445/171400 |
Related resource: | https://doi.org/10.1186/s12974-019-1531-3 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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