Please use this identifier to cite or link to this item:
Title: Variants of the aggression-related RBFOX1 gene in a population representative birth cohort study: aggressiveness, personality and alcohol use disorder
Author: Vaht, Mariliis
Laas, Kariina
Fernàndez Castillo, Noèlia
Kurrikoff, Triin
Kanarik, Margus
Faraone, Stephen V.
Tooding, Liina-Mai
Veidebaum, Toomas
Franke, Barbara
Reif, Andreas
Cormand Rifà, Bru
Harro, Jaanus
Keywords: Genètica humana
Human genetics
Issue Date: 24-Nov-2020
Publisher: Frontiers Media
Abstract: Background: Recently, RBFOX1, a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behavior. Several loci in the gene have been nominally associated with aggression in genome-wide association studies, the risk alleles being more frequent in the general population. We have hence examined the association of four RBFOX1 single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples. Methods: We used both birth cohorts of the Estonian Children Personality Behavior and Health Study (ECPBHS; original n = 1,238). Aggressiveness was assessed using the Buss-Perry Aggression Questionnaire and the Lifetime History of Aggressiveness structured interview at age 25 (younger cohort) or 33 (older cohort). Big Five personality at age 25 was measured with self-reports and the lifetime occurrence of alcohol use disorder assessed with the MINI interview. RBFOX1 polymorphisms rs809682, rs8062784, rs12921846, and rs6500744 were genotyped in all participants. Given the restricted size of the sample, correction for multiple comparisons was not applied. Results: Aggressiveness was not significantly associated with the RBFOX1 genotype. RBFOX1 rs8062784 was associated with neuroticism and rs809682 with extraversion. Two out of four analyzed RBFOX1 variants, rs8062784 and rs12921846, were associated with the occurrence of alcohol use disorder. Conclusions: In the birth cohort representative sample of the ECPBHS, no association of RBFOX1 with aggressiveness was found, but RBFOX1 variants affected basic personality traits and the prevalence of alcohol use disorder. Future studies on RBFOX1 should consider the moderating role of personality and alcohol use patterns in aggressiveness.
Note: Reproducció del document publicat a:
It is part of: Frontiers In Genetics, 2020, vol. 11, p. 501847
Related resource:
ISSN: 1664-8021
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Publicacions de projectes de recerca finançats per la UE

Files in This Item:
File Description SizeFormat 
702950.pdf343.13 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons