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Title: Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons
Author: Urrea Zazurca, Laura
Segura Feliu, Miriam
Masuda-Suzukake, Masami
Hervera Abad, Arnau
Pedraz López, Lucas
García Aznar, José Manuel
Vila, Miquel
Samitier i Martí, Josep
Torrents Serra, Eduard
Ferrer, Isidro (Ferrer Abizanda)
Gavín Marín, Rosalina
Hagesawa, Masato
Río Fernández, José Antonio del
Keywords: Alfa-sinucleïna
Issue Date: 1-Mar-2018
Publisher: Springer
Abstract: The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.
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It is part of: Molecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860
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Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
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