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http://hdl.handle.net/2445/172791
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DC Field | Value | Language |
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dc.contributor.author | Urrea Zazurca, Laura | - |
dc.contributor.author | Segura Feliu, Miriam | - |
dc.contributor.author | Masuda-Suzukake, Masami | - |
dc.contributor.author | Hervera Abad, Arnau | - |
dc.contributor.author | Pedraz López, Lucas | - |
dc.contributor.author | García Aznar, José Manuel | - |
dc.contributor.author | Vila, Miquel | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.contributor.author | Torrents Serra, Eduard | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.contributor.author | Gavín Marín, Rosalina | - |
dc.contributor.author | Hagesawa, Masato | - |
dc.contributor.author | Río Fernández, José Antonio del | - |
dc.date.accessioned | 2020-12-15T18:21:14Z | - |
dc.date.available | 2020-12-15T18:21:14Z | - |
dc.date.issued | 2018-03-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172791 | - |
dc.description.abstract | The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4 | - |
dc.relation.ispartof | Molecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860 | - |
dc.relation.uri | https://doi.org/10.1007/s12035-017-0451-4 | - |
dc.rights | cc by (c) Urrea Zazurca et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Alfa-sinucleïna | - |
dc.subject.classification | Prions | - |
dc.subject.other | Alpha-synuclein | - |
dc.subject.other | Prions | - |
dc.title | Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-12-04T12:33:49Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/228685/EU//BOND | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/278486/EU//DEVELAGE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28229331 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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UrreaL.pdf | Original Article | 18.32 MB | Adobe PDF | View/Open |
UrreaL_Err.pdf | Erratum | 271.06 kB | Adobe PDF | View/Open |
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