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http://hdl.handle.net/2445/172791
Title: | Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons |
Author: | Urrea Zazurca, Laura Segura Feliu, Miriam Masuda-Suzukake, Masami Hervera Abad, Arnau Pedraz López, Lucas García Aznar, José Manuel Vila, Miquel Samitier i Martí, Josep Torrents Serra, Eduard Ferrer, Isidro (Ferrer Abizanda) Gavín Marín, Rosalina Hagesawa, Masato Río Fernández, José Antonio del |
Keywords: | Alfa-sinucleïna Prions Alpha-synuclein Prions |
Issue Date: | 1-Mar-2018 |
Publisher: | Springer |
Abstract: | The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4 |
It is part of: | Molecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860 |
URI: | http://hdl.handle.net/2445/172791 |
Related resource: | https://doi.org/10.1007/s12035-017-0451-4 |
Appears in Collections: | Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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UrreaL.pdf | Original Article | 18.32 MB | Adobe PDF | View/Open |
UrreaL_Err.pdf | Erratum | 271.06 kB | Adobe PDF | View/Open |
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