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Title: Modularity in protein evolution: modular organization and de novo domain evolution in mollusc metallothionein
Author: Calatayud, Sara
Garcia-Risco, Mario
Pedrini-Martha, Veronika
Eernisse, Douglas J.
Dallinger, Reinhard
Palacios, Òscar
Capdevila Vidal, Mercè
Albalat Rodríguez, Ricard
Keywords: Mol·luscs
Evolució (Biologia)
Evolution (Biology)
Issue Date: 2020
Publisher: Oxford University Press
Abstract: Metallothioneins (MTs) are proteins devoted to the control of metal homeostasis and detoxification, and therefore, MTs have been crucial for the adaptation of the living beings to variable situations of metal bioavailability. The evolution of MTs is, however, not yet fully understood, and to provide new insights into it, we have investigated the MTs in the diverse classes of Mollusks. We have shown that most molluskan MTs are bimodular proteins that combine six domains α, β1, β2, β3, γ, and δ in a lineage-specific manner. We have functionally characterized the Neritimorpha β3β1 and the Patellogastropoda γβ1 MTs, demonstrating the metal-binding capacity of the new γ domain. Our results have revealed a modular organization of mollusk MT, whose evolution has been impacted by duplication, loss, and de novo emergence of domains. MTs represent a paradigmatic example of modular evolution probably driven by the structural and functional requirements of metal binding.
Note: Versió postprint del document publicat a:
It is part of: Molecular Biology and Evolution, 2021, vol. 38, num. 2, p. 424-436
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ISSN: 0737-4038
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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