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Title: Ancestral function ofInhibitors-of-kappaB regulates Caenorhabditis elegans development
Author: Brena, David
Bertran, Joan
Porta de la Riva, Montserrat
Guillen, Yolanda
Cornes, Eric
Kukhtar, Dmytro
Campos Vicens, Lluís
Fernández, Lierni
Pecharroman, Irene
García López, Albert
Islam, Abul B. M. M. K.
Marruecos, Laura
Bigas Salvans, Anna
Cerón Madrigal, Julián
Espinosa, Lluís
Keywords: Anàlisi de proteïnes
Analysis of proteins
Issue Date: 30-Sep-2020
Publisher: Nature Research
Abstract: Mammalian I kappa B proteins (I kappa Bs) exert their main function as negative regulators of NF-kappa B, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for I kappa Bs has been shown to affect stemness and cell differentiation. However, the involvement of NF-kappa B in this function has not been excluded. NFKI-1 and IKB-1 are I kappa B homologs in Caenorhabditis elegans, which lacks NF-kappa B nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans I kappa Bs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral I kappa B inhibitors modulate Polycomb activity at specific gene subsets with an impact on development.
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It is part of: Scientific Reports, 2020, vol. 10
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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