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Title: Antibiotic resistance genes in phage particles from Antarctic and Mediterranean seawater ecosystems
Author: Blanco-Picazo, Pedro
Roscales, Gabriel
Toribio-Avedillo, Daniel
Gómez-Gómez, Clara
Ávila Escartín, Conxita
Ballesté Pau, Elisenda
Muniesa Pérez, Ma Teresa
Rodríguez-Rubio, Lorena
Keywords: Ecosistemes
Resistència als medicaments
Antàrtic, Oceà
Biotic communities
Drug resistance
Antarctic Ocean
Issue Date: 24-Aug-2020
Publisher: MDPI
Abstract: Anthropogenic activities are a key factor in the development of antibiotic resistance in bacteria, a growing problem worldwide. Nevertheless, antibiotics and resistances were being generated by bacterial communities long before their discovery by humankind, and might occur in areas without human influence. Bacteriophages are known to play a relevant role in the dissemination of antibiotic resistance genes (ARGs) in aquatic environments. In this study, five ARGs (blaTEM, blaCTX-M-1, blaCTX-M-9, sul1 and tetW) were monitored in phage particles isolated from seawater of two different locations: (i) the Mediterranean coast, subjected to high anthropogenic pressure, and (ii) the Antarctic coast, where the anthropogenic impact is low. Although found in lower quantities, ARG-containing phage particles were more prevalent among the Antarctic than the Mediterranean seawater samples and Antarctic bacterial communities were confirmed as their source. In the Mediterranean area, ARG-containing phages from anthropogenic fecal pollution might allow ARG transmission through the food chain. ARGs were detected in phage particles isolated from fish (Mediterranean, Atlantic, farmed, and frozen), the most abundant being -lactamases. Some of these particles were infectious in cultures of the fecal bacteria Escherichia coli. By serving as ARG reservoirs in marine environments, including those with low human activity, such as the Antarctic, phages could contribute to ARG transmission between bacterial communities.
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It is part of: Microorganisms, 2020, vol. 8(9), num. 1293
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ISSN: 2076-2607
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
Articles publicats en revistes (Institut de Recerca de la Biodiversitat (IRBio))

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