Title: | Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies |
Author: | Munn-Chernoff, Melissa A. Johnson, Emma C. Chou, Yi Ling Coleman, Jonathan R. I. Thornton, Laura M. Walters, Raymond K. Yilmaz, Zeynep Baker, Jessica H. Hübel, Christopher Gordon, Scott Medland, Sarah E. Luykx, Jurjen Batzler, Anthony McClintick, Jeanette N. Slachtova, Lenka Gonidakis, Fragiskos Fichter, Manfred M. Santonastaso, Paolo Maes, Hermine H. Pedersen, Nancy L. Scherer, Stephen W. Männistö, Satu Shen, Pei-Hong Mattheisen, Manuel Hack, Laura M. Rabionet Janssen, Raquel Mullan Harris, Kathleen Johnson, Eric O. Tyszkiewicz-Nwafor, Marta Crowley, James J. Hottenga, Jouke Jan Palotie, Aarno Karwautz, Andreas Witt, Stephanie H. McGuffin, Peter Giusti Rodríguez, Paola Ramoz, Nicolas Lahti Pulkkinen, Marius Tarter, Ralph E. Mannik, Katrin Ophoff, Roel A. Karpyak, Victor M. Culverhouse, Robert C. Papezova, Hana Penninx, Brenda W. J. H. Werge, Thomas Dong, Li Meulenbelt, Ingrid Kalsi, Gursharan La Via, Maria C. Zerwas, Stephanie Strober, Michael Giegling, Ina Palviainen, Teemu McQueen, Matthew B. Lissowska, Jolanta Copeland, William E. Edwards, Alexis C. Danner, Unna N. Magnusson, Patrik K. E. Meyers, Jacquelyn L. Szatkiewicz, Jin P. Brandt, Harry Kim, Youl R. Preuss, Ulrich Nurnberger, John I Boraska Perica, Vesna Hayward, Caroline Gelernter, Joel Dina, Christian Forzan, Monica Martin, Nicholas G. Iacono, William G. Foo, Jerome C. Degenhardt, Louisa Docampo, Elisa Lind, Penelope A. Zhou, Hang Wetherill, Leah Cichon, Sven Clementi, Maurizio Scherbaum, Norbert Duncan, Laramie E. Monteleone, Alessio Maria Alfredsson, Lars Schork, Nicholas J. Hodgkinson, Colin Schwandt, Melanie Foroud, Tatiana M. Danae Lin, Bochao Kas, Martien J.H. Choi, Doo-Sup Ritschel, Franziska Schosser, Alexandra Ntalla, Ioanna Kramer, John Ising, Marcus Fischer, Krista Kaminská, Deborah Gallinger, Steven Ridinger, Monika Horwood, L. John Jordan, Jennifer Riley, Brien P. Biernacka, Joanna M. Goldman, David Hinney, Anke Widen, Elisabeth Wills, Amanda G. Bacanu, Silviu Alin Slof-Op't Landt, Margarita C. T. Brown, Sandra A. McIntosh, Andrew M. Föcker, Manuel Hauser, Joanna Ehrlich, Stefan Clarke, Toni-Kim Kaplan, Allan S. Hancock, Dana B. Hopfer, Christian J. Foretova, Lenka Schosser, Jochen Degenhardt, Franziska Adkins, Daniel E. Slopien, Agnieszka Zhao, Hongyu Burghardt, Roland Adkins, Amy E. Mann, Karl Tortorella, Alfonso Tziouvas, Konstantinos Marshall, Christian R. Thomas, Nathaniel Klump, Kelly L. Vanyukov, Michael M. Lucae, Susanne Boehm, Ilka Henders, Anjali K. Wang, Jen-Chyong Tozzi, Federica Bigdeli, Tim B. Parker, Richard Larsen, Janne T. Marsal, Sara Bo Mortensen, Preben Crow, Scott Mitchell, Karen Ligthart, Lannie Giuranna, Johanna Janout, Vladimir Heilmann Heimbach, Stefanie Kiefer, Falk Imgart, Hartmut Landén, Mikael DeSocio, Janiece E. Edenberg, Howard J. Soyka, Michael Walton, Esther Jiménez-Murcia, Susana Davis, Oliver S. P. Micali, Nadia Müller Myhsok, Bertram Hellard, Stephanie Le Keski Rahkonen, Anna Mattingsdal, Morten Sullivan, Patrick F. Rietschel, Marcella Dikeos, Dimitris Hartmann, Annette M. Lahti, Jari Webb, Bradley T. Hudson, James I. Diazgranados, Nancy Karhunen, Leila Sorbi, Sandro Domingue, Benjamin W. Hebebrand, Johannes Gratacos Mayora, Monica Cone, Roger D. Andreassen, Ole A. Dedoussis, George Krauter, Kenneth Estivill, Xavier, 1955- Costello, E. Jane Guillaume, Sébastien Navratilova, Marie Rose, Richard J. Leppä, Virpi M. Sanchez Roige, Sandra Kennedy, James L. Rybakowski, Filip Whitfield, John B. Tsitsika, Artemis Crawford, Steven Treutlein, Jens Keyes, Margaret Świątkowska, Beata Heath, Andrew C. Zeggini, Eleftheria Treasure, Janet Monteleone, Palmiero Vrieze, Scott Pearson, John F. McGue, Matt Nöthen, Markus M. Bergen, Andrew W. Nacmias, Benedetta Räikkönen, Katri Bryois, Julien Herms, Stefan Ricca, Valdo Wit, Harriet de Wall, Tamara L. Esko, Tõnu Padyukov, Leonid Guo, Yiran Rice, John P. Pantel, Jacques Grove, Jakob Dongbing, Lai Milaneschi, Yuri Helder, Sietske G. Herzog, Wolfgang Schuckit, Marc A. Courtet, Philippe Konte, Bettina Goate, Alison M. Maj, Mario Palmer, Abraham A. Maier, Wolfgang Farrer, Lindsay A. Frye, Mark A. Raevuori, Anu Franklin, Christopher S. Hoffmann, Per Strohmaier, Jana Kuperman, Samuel Bulik, Cynthia M. Inoko, Hidetoshi Sherva, Richard Montgomery, Grant W. Huckins, Laura M. Egberts, Karim Kaprio, Jaakko Lichtenstein, Paul Bertelsen, Sarah Bucholz, Kathleen K. Metspalu, Andres Kiezebrink, Kirsty Docherty, Anna R. Wodarz, Norbert Van Elburg, Annemarie A. Stallings, Michael C. Kennedy, Martin A Levitan, Robert D. Ripke, Stephan Aliev, Fazil Murray, Alison D. Norring, Claes Buehren, Katharina Gäbel, Wolfgang Boardman, Jason D. Woodside, D. Blake Wagner, Gudrun Cassina, Matteo Neale, Benjamin M. Ando, Tetsuya O'Toole, Julie K. Yao, Shuyang Grucza, Richard A. Reichborn Kjennerud, Tez Streit, Fabian Julià, Antonio Lynskey, Michael T. Kranzler, Henry R. Knudsen, Gun Peggy S. Gorwood, Philip Halmi, Katherine A. Degortes, Daniela Tenconi, Elena Maher, Brion S. Li-Shiun , Chen Watson, Hunna J. Adan, Roger A. H. Dick, Danielle M. McDevitt, Sara Hartz, Sarah M. Madden, Pamela A.F . Nelson, Elliot C. Wade, Tracey D. Chen, Danfeng Kaye, Walter H. Olsen, Catherine M. Tachmazidou, Ioanna Eriksson, Johan G. Slagboom, P. Eline Loukola, Anu Birgegård, Andreas Bierut, Laura J. Rujescu, Dan Hewitt, John K. Hatzikotoulas, Konstantinos Kendler, Kenneth S. Saccone, Nancy L. Johnson, Craig Dmitrzak Weglarz, Monika Zipfel, Stephan Hanscombe, Ken B. Agrawal, Arpana Roberts, Marion Pinto, Dalila Peterson, Roseann E. Gaspar, Héléna A. Reynolds, Maureen D. Breen, Gerome Gillespie, Nathan A. Boni, Claudette Hakonarson, Hakon Fox, Louis Rotondo, Alessandro Escaramís Babiano, Geòrgia Forstner, Andreas J. Van Furth, Eric F. Salvatore, Jessica E. Porjesz, Bernice Berrettini, Wade H. Boomsma, Dorret I. Koller, Gabriele Wedow, Robbee Frank, Josef Ripatti, Samuli Magistretti, Pierre J. Polimanti, Renato Schmidt, Ulrike Zwaan, Martina de Boden, Joseph M. Zill, Peter Mitchell, James Ryu, Euijung Scherag, André MacKillop, James Mbarek, Hamdi Herpertz-Dahlmann, Beate Hesselbrock, Victor Dahmen, Norbert Lilenfeld, Lisa Silberg, Judy |
Keywords: | Trastorns de la conducta alimentària Genètica Factors de risc en les malalties Fenotip Consum d'alcohol Abús de substàncies Eating disorders Genetics Risk factors in diseases Phenotype Drinking of alcoholic beverages Substance abuse |
Issue Date: | 16-Feb-2020 |
Publisher: | Wiley |
Abstract: | Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1111/adb.12880 |
It is part of: | Addiction Biology, 2020, vol. 26(1), num. e12880 |
URI: | http://hdl.handle.net/2445/174530 |
Related resource: | https://doi.org/10.1111/adb.12880 |
ISSN: | 1355-6215 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Genètica, Microbiologia i Estadística)
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.