Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175417
Title: | Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels |
Author: | Tort-Merino, Adrià Olives, Jaume León, María Peñaloza, Claudia Valech, Natalia Santos-Santos, Miguel A. Camara Mancha, Estela Grönholm-Nyman, Petra Martínez-Lage Álvarez, Pablo Fortea, Juan Molinuevo, José Luis Sánchez del Valle Díaz, Raquel Laine, Matti Rodríguez Fornells, Antoni Rami, Lorena |
Keywords: | Malaltia d'Alzheimer Trastorns de la memòria Envelliment cerebral Marcadors bioquímics Alzheimer's disease Memory disorders Aging brain Biochemical markers |
Issue Date: | 2-Jul-2019 |
Publisher: | IOS Press |
Abstract: | Background: We investigated a sample of cognitively healthy subjects with normal Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker levels to identify the earliest variables related to longitudinal memory changes. Objective: Employing a new highly demanding learning and memory test (the Ancient Farming Equipment Test; AFE-T), we aimed to investigate whether a biomarker related to neurodegeneration (i.e., CSF tau) was associated with longitudinal memory decline. Methods: Thirty-two cognitively and biologically normal (CBN) subjects underwent MRI, neuropsychological assessment, and the AFE-T at baseline and 18 months later. To explore the relationship between cognitive performance and relevant factors, a linear model was set up. For a secondary analysis that further explore the effect of tau, the subjects were divided into CBN-Tau↓ (tau < 228.64 pg/ml; n = 16) and CBN-Tau↑ (tau > 228.64 pg/ml; n = 16). We also performed voxel-based morphometry (VBM) to identify regions of grey matter volume that would predict both baseline and longitudinal cognitive performance. Results: Our main finding was an association between CSF tau and longitudinal memory decline measured with AFE-T (B = -0.17, p < 0.05; r = -0.414; p < 0.01), and further analyses showed different evolvement between subgroups, with an accelerated decline in individuals with higher tau (F(1,31) = 8.37; p < 0.01). VBM results suggested that AFE-T performance is related to grey matter volume in a medial temporal, middle frontal, and posterior cerebellar network at baseline, and that there are strategic brain areas driving the longitudinal cognitive changes. Conclusions: The present findings provide evidence for structural and biological markers linked to cognitive aging by highlighting the role of tau, a marker of neurodegeneration, which can be related with the earliest memory changes in healthy subjects. |
Note: | Reproducció del document publicat a: https://doi.org/10.3233/JAD-190046 |
It is part of: | Journal of Alzheimer's Disease, 2019, vol. 70, num. 1, p. 211-225 |
URI: | http://hdl.handle.net/2445/175417 |
Related resource: | https://doi.org/10.3233/JAD-190046 |
ISSN: | 1387-2877 |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
705008.pdf | 1.49 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.