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Title: Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial
Author: Hernáez, Álvaro
Lassale, Camille
Castro Barquero, Sara
Ros Rahola, Emilio
Tresserra i Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Vázquez Ruiz, Zenaida
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Razquin, Cristina
Corella Piquer, Dolores
Guasch Ferré, Marta
Cofán Pujol, Montserrat
Estruch Riba, Ramon
Keywords: Dieta
Cuina mediterrània
Factors de risc en les malalties
Assaigs clínics
Mediterranean cooking
Risk factors in diseases
Clinical trials
Issue Date: 8-Feb-2021
Publisher: MDPI
Abstract: here is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
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It is part of: Nutrients, 2021, vol. 13, num. 2, p. 599-572
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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