Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175995
Title: | Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage |
Author: | Marazuela, Paula Bonaterra Pastra, Anna Faura, Júlia Penalba, Anna Pizarro, Jesús Pancorbo, Olalla Rodríguez Luna, David Vert, Carla Rovira, Alex Pujadas, Francesc Freijo, M. Mar Tur, Silvia Martínez Zabaleta, Maite Cardona Portela, Pere Vera, Rocío Lebrato Hernández, Lucia Arenillas, Juan F. Pérez Sánchez, Soledad Montaner, Joan Delgado, Pilar Hernández Guillamon, Mar |
Keywords: | Hemorràgia Malalties del sistema nerviós central Ressonància magnètica Hemorrhage Central nervous system diseases Magnetic resonance |
Issue Date: | 2-Mar-2021 |
Publisher: | MDPI |
Abstract: | Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10050989 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10, num. 5 |
URI: | http://hdl.handle.net/2445/175995 |
Related resource: | https://doi.org/10.3390/jcm10050989 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
jcm-10-00989.pdf | 1.04 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License