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Title: Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial
Author: Castro Barquero, Sara
Ribó-Coll, Margarita
Lassale, Camille
Tresserra i Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Martínez-González, Miguel Ángel, 1957-
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Basterra Gortari, F. Javier
Portolés, Olga
Babio, Nancy
Cofán Pujol, Montserrat
Ros Rahola, Emilio
Estruch Riba, Ramon
Hernáez, Álvaro
Keywords: Dieta
Cuina mediterrània
Vitamines K
Malalties cardiovasculars
Mediterranean cooking
Vitamin K
Cardiovascular diseases
Issue Date: 1-Dec-2020
Publisher: MDPI
Abstract: Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46-0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92-9.30], HRMedDiets: 1.71 [0.83-3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2020, vol. 12, num. 12
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Ciències Clíniques)

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