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Title: Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
Author: Martínez Molina, Noelia
Siponkoski, Sini-Tuuli
Kuusela, Linda
Laitinen, Sari
Holma, Milla
Ahlfors, Mirja
Jordan-Kilkki, Päivi
Ala-Kauhaluoma, Katja
Melkas, Susanna
Pekkola, Johanna
Rodríguez Fornells, Antoni
Laine, Matti
Ylinen, Aarne
Rantanen, Pekka
Koskinen, Sanna
Cowley, Benjamin Ultan
Särkämö, Teppo
Keywords: Traumatismes cranials
Skull injuries
Music therapy
Issue Date: 8-Mar-2021
Publisher: Hindawi Limited
Abstract: Traumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music therapy intervention enhanced executive function (EF) and increased grey matter volume in the right inferior frontal gyrus (IFG) in patients with moderate-to-severe TBI (N = 40). Extending this study, we performed longitudinal rsFC analyses of resting-state fMRI data using a ROI-to-ROI approach assessing within-network and between-network rsFC in the frontoparietal (FPN), dorsal attention (DAN), default mode (DMN), and salience (SAL) networks, which all have been associated with cognitive impairment after TBI. We also performed a seed-based connectivity analysis between the right IFG and whole-brain rsFC. The results showed that neurological music therapy increased the coupling between the FPN and DAN as well as between these networks and primary sensory networks. By contrast, the DMN was less connected with sensory networks after the intervention. Similarly, there was a shift towards a less connected state within the FPN and SAL networks, which are typically hyperconnected following TBI. Improvements in EF were correlated with rsFC within the FPN and between the DMN and sensorimotor networks. Finally, in the seed-based connectivity analysis, the right IFG showed increased rsFC with the right inferior parietal and left frontoparietal (Rolandic operculum) regions. Together, these results indicate that the rehabilitative effects of neurological music therapy after TBI are underpinned by a pattern of within- and between-network connectivity changes in cognitive networks as well as increased connectivity between frontal and parietal regions associated with music processing.
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It is part of: Neural Plasticity, 2021, vol. 2021
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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