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Title: Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus
Author: Almanza Aguilera, Enrique
Hernáez Camba, Álvaro
Corella Piquer, Dolores
Sanllorente, Albert
Ros Rahola, Emilio
Portoles, Olga
Valussi, Julieta
Estruch Riba, Ramon
Coltell, Óscar
Subirana Cachinero, Isaac
Canudas Puig, Sílvia
Razquin, Cristina
Blanchart, Gemma
Nonell, Lara
Fitó Colomer, Montserrat
Castañer, Olga
Keywords: Diabetis no-insulinodependent
Cèl·lules T
Non-insulin-dependent diabetes
T cells
Issue Date: 29-Dec-2020
Publisher: MDPI
Abstract: We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini-Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant 'upregulation' and ≤ -2.0 'downregulation'). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, -log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, -log(p-value) = 2.03) and paxillin (z-score = 2.33, -log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = -2.14, -log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
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It is part of: Journal of Clinical Medicine, 2020, vol. 10, num. 1, p. 85
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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