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http://hdl.handle.net/2445/176069
Title: | Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus |
Author: | Almanza Aguilera, Enrique Hernáez Camba, Álvaro Corella Piquer, Dolores Sanllorente, Albert Ros Rahola, Emilio Portoles, Olga Valussi, Julieta Estruch Riba, Ramon Coltell, Óscar Subirana Cachinero, Isaac Canudas Puig, Sílvia Razquin, Cristina Blanchart, Gemma Nonell, Lara Fitó Colomer, Montserrat Castañer, Olga |
Keywords: | Diabetis no-insulinodependent Cèl·lules T Càncer Non-insulin-dependent diabetes T cells Cancer |
Issue Date: | 29-Dec-2020 |
Publisher: | MDPI |
Abstract: | We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini-Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant 'upregulation' and ≤ -2.0 'downregulation'). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, -log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, -log(p-value) = 2.03) and paxillin (z-score = 2.33, -log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = -2.14, -log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10010085 |
It is part of: | Journal of Clinical Medicine, 2020, vol. 10, num. 1, p. 85 |
URI: | http://hdl.handle.net/2445/176069 |
Related resource: | https://doi.org/10.3390/jcm10010085 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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