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Title: | Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases |
Author: | Palmas, Lucia Aroffu, Matteo Petretto, Giacomo L. Escribano Ferrer, Elvira Díez Sales, Octavio Usach, Iris Peris, José Esteban Marongiu, Francesca Ghavam, Mansureh Fais, Sara Orrù, Germano Rached, Rita Abi Manca, Maria Letizia Manconi, Maria |
Keywords: | Olis essencials Llimones Malalties de la boca Estreptococs Essences and essential oils Lemons Mouth diseases Streptococcus |
Issue Date: | 28-Aug-2020 |
Publisher: | MDPI |
Abstract: | This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacterium |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ph13090216 |
It is part of: | Pharmaceuticals, 2020, vol. 13, num. 9, p. 216 |
URI: | http://hdl.handle.net/2445/176075 |
Related resource: | https://doi.org/10.3390/ph13090216 |
ISSN: | 1424-8247 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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