Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176178
Title: | Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study |
Author: | Josa Laorden, Claudia Crestelo Vieitez, Anxela García Andreu, María Rubio-Rivas, Manuel Sánchez, Marcos Toledo Samaniego, Neera Arnalich Fernández, Francisco Iguaran Bermudez, Rosario Fonseca Aizpuru, Eva Vargas Núñez, Juan Antonio Pesqueira Fontan, Paula Maria Serrano Ballesteros, Jorge Freire Castro, Santiago Pestaña Fernández, Melani Viana García, Alba Nuñez Rodriguez, Victoria Giner Galvañ, Vicente Carrasco Sánchez, Francisco Hernández Milián, Almudena Cobos Siles, Marta Napal Lecumberri, Jose Herrero García, Virginia Pascual Pérez, Maria Millán Núñez-Cortés, Jesús Casas Rojo, José SEMI-COVID-19 Network |
Keywords: | Factors sexuals en les malalties SARS-CoV-2 COVID-19 Espanya Sex factors in disease SARS-CoV-2 COVID-19 Spain |
Issue Date: | 25-Feb-2021 |
Publisher: | MDPI |
Abstract: | There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10050899 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10, num. 5 |
URI: | http://hdl.handle.net/2445/176178 |
Related resource: | https://doi.org/10.3390/jcm10050899 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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