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Title: Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
Author: Camilleri-Robles, Carlos
Serras Rigalt, Florenci
Corominas, Montserrat (Corominas Guiu)
Keywords: Proteïnes G
G Proteins
Issue Date: 18-May-2019
Publisher: MDPI
Abstract: The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
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It is part of: Genes, 2019, vol. 10, num. 5, p. 378
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ISSN: 2073-4425
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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