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Title: | Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype |
Author: | Lope, Virginia Guerrero Zotano, Ángel Casas, Ana Baena Cañada, José Manuel Bermejo, Begona Pérez Gómez, Beatriz Criado Navarro, Inmaculada Antolín, Silvia Sánchez Rovira, Pedro Ramos Vázquez, Manuel Antón, Antonio Castelló, Adela García Saenz, Jose Angel Muñoz Mateu, Montserrat Juan, Ana de Andrés, Raquel Llombart Cussac, Antonio Hernando, Blanca Franquesa, Rosa María Caballero, Rosalía Priego Capote, Feliciano Martón, Miguel Pollán, Marina |
Keywords: | Càncer de mama Àcids grassos Breast cancer Fatty acids |
Issue Date: | 1-Oct-2020 |
Publisher: | MDPI |
Abstract: | This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu12103132 |
It is part of: | Nutrients, 2020, vol. 12, num. 10 |
URI: | http://hdl.handle.net/2445/176311 |
Related resource: | https://doi.org/10.3390/nu12103132 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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