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Title: Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
Author: Lope, Virginia
Guerrero Zotano, Ángel
Casas, Ana
Baena Cañada, José Manuel
Bermejo, Begona
Pérez Gómez, Beatriz
Criado Navarro, Inmaculada
Antolín, Silvia
Sánchez Rovira, Pedro
Ramos Vázquez, Manuel
Antón, Antonio
Castelló, Adela
García Saenz, Jose Angel
Muñoz Mateu, Montserrat
Juan, Ana de
Andrés, Raquel
Llombart Cussac, Antonio
Hernando, Blanca
Franquesa, Rosa María
Caballero, Rosalía
Priego Capote, Feliciano
Martón, Miguel
Pollán, Marina
Keywords: Càncer de mama
Àcids grassos
Breast cancer
Fatty acids
Issue Date: 1-Oct-2020
Publisher: MDPI
Abstract: This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
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It is part of: Nutrients, 2020, vol. 12, num. 10
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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