Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176325
Title: | Epigenetics in Cancer |
Author: | Esteller, Manel |
Keywords: | ADN Epigènesi Expressió gènica Proteïnes supressores de tumors Fisiologia DNA Epigenesis Gene expression Tumor suppressor protein Physiology |
Issue Date: | 13-Mar-2008 |
Publisher: | Massachusetts Medical Society |
Abstract: | Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence. |
Note: | Reproducció del document publicat a: https://doi.org/10.1056/NEJMra072067 |
It is part of: | New England Journal of Medicine, 2008, vol. 358, num. 11, p. 1148-1159 |
URI: | http://hdl.handle.net/2445/176325 |
Related resource: | https://doi.org/10.1056/NEJMra072067 |
ISSN: | 0028-4793 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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699623.pdf | 472.47 kB | Adobe PDF | View/Open |
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