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Title: Brain Volumetric Correlates of Right Unilateral Versus Bitemporal Electroconvulsive Therapy for Treatment-Resistant Depression.
Author: Cano Català, Marta
Lee, Erik
Cardoner, N. (Narcís)
Martínez Zalacaín, Ignacio
Pujol, Jesús
Makris, Nikos
Henry, Michael
Via, Esther
Hernández Ribas, Rosa
Contreras Rodríguez, Oren
Menchón Magriñá, José Manuel
Urretavizcaya Sarachaga, Mikel
Soriano Mas, Carles
Camprodon, Joan A.
Keywords: Depressió psíquica
Diagnòstic per la imatge
Mental depression
Diagnostic imaging
Issue Date: 2019
Publisher: American Psychiatric Association
Abstract: Objective: The selection of a bitemporal (BT) or right unilateral (RUL) electrode placement affects the efficacy and side effects of ECT. Previous studies have not entirely described the neurobiological underpinnings of such differential effects. Recent neuroimaging research on gray matter volumes is contributing to our understanding of the mechanism of action of ECT and could clarify the differential mechanisms of BT and RUL ECT. Methods: To assess the whole-brain gray matter volumetric changes observed after treating patients with treatment-resistant depression with BT or RUL ECT, the authors used MRI to assess 24 study subjects with treatment-resistant depression (bifrontotemporal ECT, N=12; RUL ECT, N=12) at two time points (before the first ECT session and after ECT completion). Results: Study subjects receiving BT ECT showed gray matter volume increases in the bilateral limbic system, but subjects treated with RUL ECT showed gray matter volume increases limited to the right hemisphere. The authors observed significant differences between the two groups in midtemporal and subcortical limbic structures in the left hemisphere. Conclusions: These findings highlight that ECT-induced gray matter volume increases may be specifically observed in the stimulated hemispheres. The authors suggest that electrode placement may relevantly contribute to the development of personalized ECT protocols.
Note: Versió postprint del document publicat a:
It is part of: Journal of Neuropsychiatry and Clinical Neurosciences, 2019, vol. 31, num. 2, p. 152-158
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ISSN: 0895-0172
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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