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DC Field | Value | Language |
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dc.contributor.author | Oliva, Natalia de la | - |
dc.contributor.author | Mueller, Matthias | - |
dc.contributor.author | Stieglitz, Thomas | - |
dc.contributor.author | Navarro, X. (Xavier) | - |
dc.contributor.author | Valle i Macià, Jaume del | - |
dc.date.accessioned | 2021-05-04T20:14:37Z | - |
dc.date.available | 2021-05-04T20:14:37Z | - |
dc.date.issued | 2018-04-13 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177002 | - |
dc.description.abstract | Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. We evaluated 1-year-aged in vitro samples, where no chemical differences were observed and only a slight deviation on Young's modulus was found. The foreign body reaction (FBR) to longitudinal Parylene C devices implanted in the rat sciatic nerve for 8 months was characterized. After 2 weeks, a capsule was formed around the device, which continued increasing up to 16 and 32 weeks. Histological analyses revealed two cell types implicated in the FBR: macrophages, in contact with the device, and fibroblasts, localized in the outermost zone after 8 weeks. Molecular analysis of implanted nerves comparing Parylene C and polyimide devices revealed a peak of inflammatory cytokines after 1 day of implant, returning to low levels thereafter. Only an increase of CCL2 and CCL3 was found at chronic time-points for both materials. Although no molecular differences in the FBR to both polymers were found, the thick tissue capsule formed around Parylene C puts some concern on its use as a scaffold for intraneural electrodes. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-24502-z | - |
dc.relation.ispartof | Scientific Reports, 2018, vol. 8, num. 1, p. 5965 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-018-24502-z | - |
dc.rights | cc-by (c) Oliva, Natalia de la et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Polímers en medicina | - |
dc.subject.classification | Pròtesis internes | - |
dc.subject.other | Polymers in medicine | - |
dc.subject.other | Stents (Surgery) | - |
dc.title | On the use of Parylene C polymer as substrate for peripheral nerve electrodes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707661 | - |
dc.date.updated | 2021-05-04T20:14:38Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/611687/EU//NEBIAS | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29654317 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Bioquímica i Fisiologia) |
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707661.pdf | 2.65 MB | Adobe PDF | View/Open |
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