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Title: | On the use of Parylene C polymer as substrate for peripheral nerve electrodes |
Author: | Oliva, Natalia de la Mueller, Matthias Stieglitz, Thomas Navarro, X. (Xavier) Valle i Macià, Jaume del |
Keywords: | Polímers en medicina Pròtesis internes Polymers in medicine Stents (Surgery) |
Issue Date: | 13-Apr-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. We evaluated 1-year-aged in vitro samples, where no chemical differences were observed and only a slight deviation on Young's modulus was found. The foreign body reaction (FBR) to longitudinal Parylene C devices implanted in the rat sciatic nerve for 8 months was characterized. After 2 weeks, a capsule was formed around the device, which continued increasing up to 16 and 32 weeks. Histological analyses revealed two cell types implicated in the FBR: macrophages, in contact with the device, and fibroblasts, localized in the outermost zone after 8 weeks. Molecular analysis of implanted nerves comparing Parylene C and polyimide devices revealed a peak of inflammatory cytokines after 1 day of implant, returning to low levels thereafter. Only an increase of CCL2 and CCL3 was found at chronic time-points for both materials. Although no molecular differences in the FBR to both polymers were found, the thick tissue capsule formed around Parylene C puts some concern on its use as a scaffold for intraneural electrodes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-24502-z |
It is part of: | Scientific Reports, 2018, vol. 8, num. 1, p. 5965 |
URI: | http://hdl.handle.net/2445/177002 |
Related resource: | https://doi.org/10.1038/s41598-018-24502-z |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Bioquímica i Fisiologia) |
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