Please use this identifier to cite or link to this item:
Title: Poor glycemic control in type 2 diabetes enhances functional and compositional alterations of small, dense HDL3c
Author: Gomez Rosso, Leonardo
Lhomme, Marie
Meroño, Tomás
Dellepiane, Ana
Sorroche, Patricia
Hedjazi, Lyamine
Zakiev, Emile
Sukhorukov, Vasily
Orekhov, Alexander
Gasparri, Julieta
Chapman, M. John
Brites, Fernando
Kontush, Anatol
Keywords: Hiperlipoproteïnes
High density lipoproteins
Blood sugar
Issue Date: 2-Nov-2016
Publisher: Elsevier B.V.
Abstract: High-density lipoprotein (HDL) possesses multiple biological activities; small, dense HDL3c particles displaying distinct lipidomic composition exert potent antiatherogenic activities which can be compromised in dyslipidemic, hyperglycemic insulin-resistant states. However, it remains indeterminate (i) whether such functional HDL deficiency is related to altered HDL composition, and (ii) whether it originates from atherogenic dyslipidemia, dysglycemia, or both. In the present work we analyzed compositional characteristics of HDL subpopulations and functional activity of small, dense HDL3c particles in treatment-naïve patients with well-controlled (n=10) and poorly-controlled (n=8) type 2 diabetes (T2D) and in normolipidemic age- and sex-matched controls (n=11). Our data reveal that patients with both well- and poorly-controlled T2D displayed dyslipidemia and low-grade inflammation associated with altered HDL composition. Such compositional alterations in small, dense HDL subfractions were specifically correlated with plasma HbA1c levels. Further analysis using a lipidomic approach revealed that small, dense HDL3c particles from T2D patients with poor glycemic control displayed additional modifications of their chemical composition. In parallel, antioxidative activity of HDL3c towards oxidation of low-density lipoprotein was diminished. These findings indicate that defective functionality of small, dense HDL particles in patients with T2D is not only affected by the presence of atherogenic dyslipidemia, but also by the level of glycemic control, reflecting compositional alterations of HDL. Keywords: Antioxidative activity; Functionality; HDL; Lipidomics; Type 2 diabetes.
Note: Versió postprint del document publicat a:
It is part of: Biochimica et Biophysica Acta, 2016
Related resource:
ISSN: 0006-3002
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Files in This Item:
File Description SizeFormat 
712172.pdf354.24 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons