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Title: Host- and Pathogen-Related Factors for Acute Cardiac Events in Pneumococcal Pneumonia
Author: Rombauts, Alexander
Abelenda Alonso, Gabriela
Càmara, Jordi
Lorenzo Esteller, Laia
González-Díaz, Aida
Sastre Escolà, Enric
Gudiol González, Carlota
Dorca i Sargatal, Jordi
Tebé, Cristian
Pallarès, Natàlia
Ardanuy Tisaire, María Carmen
Carratalà, Jordi
Keywords: Pneumònia adquirida a la comunitat
Malalties del cor
Community-acquired pneumonia
Heart diseases
Issue Date: 26-Oct-2020
Publisher: Oxford University Press
Abstract: Background: Acute cardiac events (ACEs) are increasingly being recognized as a major complication in pneumococcal community-acquired pneumonia (CAP). Information regarding host- and pathogen-related factors for ACEs, including pneumococcal serotypes and clonal complexes, is scarce. Methods: A retrospective study was conducted of a prospective cohort of patients hospitalized for CAP between 1996 and 2019. Logistic regression and funnel plot analyses were performed to determine host- and pathogen-related factors for ACEs. Results: Of 1739 episodes of pneumococcal CAP, 1 or more ACEs occurred in 304 (17.5%) patients, the most frequent being arrhythmia (n = 207), heart failure (n = 135), and myocardial infarction (n = 23). The majority of ACEs (73.4%) occurred within 48 hours of admission. Factors independently associated with ACEs were older age, preexisting heart conditions, pneumococcal bacteremia, septic shock at admission, and high-risk pneumonia. Among 983 pneumococcal isolates, 872 (88.7%) were serotyped and 742 (75.5%) genotyped. The funnel plot analyses did not find any statistically significant association between serotypes or clonal complexes with ACEs. Nevertheless, there was a trend toward an association between CC230 and these complications. ACEs were independently associated with 30-day mortality (adjusted odds ratio, 1.88; 95% CI, 1.11-3.13). Conclusions: ACEs are frequent in pneumococcal pneumonia and are associated with increased mortality. The risk factors defined in this study may help identify patients who must undergo close follow-up, including heart rhythm monitoring, and special care to avoid fluid overload, particularly during the first 48 hours of admission. These high-risk patients should be the target for preventive intervention strategies.
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It is part of: Open Forum Infectious Diseases, 2020, vol. 7, num. 12
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ISSN: 2328-8957
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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