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dc.contributor.authorRicolo, Delia-
dc.contributor.authorAraújo, Sofia J.-
dc.description.abstractSubcellular lumen formation by single-cells involves complex cytoskeletal remodelling. We have previously shown that centrosomes are key players in the initiation of subcellular lumen formation in Drosophila melanogaster, but not much is known on the what leads to the growth of these subcellular luminal branches or makes them progress through a particular trajectory within the cytoplasm. Here, we have identified that the spectraplakin Short-stop (Shot) promotes the crosstalk between MTs and actin, which leads to the extension and guidance of the subcellular lumen within the Terminal Cell (TC) cytoplasm. Shot is enriched in cells undergoing the initial steps of subcellular branching as a direct response to FGF signalling. An excess of Shot induces ectopic acentrosomal luminal branching points in the embryonic and larval tracheal TC leading to cells with extra subcellular lumina. These data provide the first evidence for a role for spectraplakins in single-cell lumen formation and branching.-
dc.format.extent29 p.-
dc.publishereLife Sciences-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofeLife, 2020, vol. 9, p. e61111-
dc.rightscc-by (c) Ricolo, Delia et al., 2020-
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)-
dc.subject.classificationProteïnes citosquelètiques-
dc.subject.classificationDrosòfila melanogaster-
dc.subject.otherCytoskeletal proteins-
dc.subject.otherDrosophila melanogaster-
dc.titleCoordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching-
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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