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Title: Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes
Author: Kennington, Stuart C. D.
Teloxa, Saul F.
Mellado Hidalgo, Miguel
Galeote, Oriol
Puddu, Sabrina
Bellido, Marina
Romea, Pedro
Urpí Tubella, Fèlix
Aullón López, Gabriel
Font Bardia, Ma. Mercedes
Keywords: Reacció aldòlica
Síntesi asimètrica
Aldol reaction
Asymmetric synthesis
Issue Date: 5-Jul-2021
Publisher: Wiley-VCH
Abstract: A direct and asymmetric aldol reaction of N-acylthiazinanethiones with aromatic aldehydes catalyzed by chiralnickel(II) complexes is reported. The reaction gives thecorresponding O-TIPS-protected anti-aldol adducts in highyields and with remarkable stereocontrol and atom economy.Furthermore, the straightforward removal of the achiralscaffold provides enantiomerically pure intermediates ofsynthetic interest, which involve precursors for anti-a-amino-b-hydroxy anda,b-dihydroxy carboxylic derivatives. Theoret-ical calculations explain the observed high stereocontrol.
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It is part of: Angewandte Chemie-International Edition, 2021, vol. 60, num. 28, p. 15307-15312
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ISSN: 1433-7851
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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