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Title: | Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes |
Author: | Kennington, Stuart C. D. Teloxa, Saul F. Mellado Hidalgo, Miguel Galeote, Oriol Puddu, Sabrina Bellido, Marina Romea, Pedro Urpí Tubella, Fèlix Aullón López, Gabriel Font Bardia, Ma. Mercedes |
Keywords: | Reacció aldòlica Síntesi asimètrica Níquel Aldol reaction Asymmetric synthesis Nickel |
Issue Date: | 5-Jul-2021 |
Publisher: | Wiley-VCH |
Abstract: | A direct and asymmetric aldol reaction of N-acylthiazinanethiones with aromatic aldehydes catalyzed by chiralnickel(II) complexes is reported. The reaction gives thecorresponding O-TIPS-protected anti-aldol adducts in highyields and with remarkable stereocontrol and atom economy.Furthermore, the straightforward removal of the achiralscaffold provides enantiomerically pure intermediates ofsynthetic interest, which involve precursors for anti-a-amino-b-hydroxy anda,b-dihydroxy carboxylic derivatives. Theoret-ical calculations explain the observed high stereocontrol. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/anie.202104352 |
It is part of: | Angewandte Chemie-International Edition, 2021, vol. 60, num. 28, p. 15307-15312 |
URI: | http://hdl.handle.net/2445/178957 |
Related resource: | https://doi.org/10.1002/anie.202104352 |
ISSN: | 1433-7851 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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