Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178991
Title: Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
Author: Ramchuran, Estelle J.
Pérez-Guillén, Isabel
Bester, Linda A.
Khan, René
Albericio Palomera, Fernando
Viñas, Miquel
Torre, Beatriz G. de la
Keywords: Síntesi en fase sólida
Pèptids
Antibiòtics
Bacteris gramnegatius
Solid-phase synthesis
Peptides
Antibiotics
Gram-negative bacteria
Issue Date: 10-Jun-2021
Publisher: MDPI
Abstract: Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.
Note: Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10060695
It is part of: Antibiotics, 2021, vol. 10, num. 6, p. 695
URI: http://hdl.handle.net/2445/178991
Related resource: https://doi.org/10.3390/antibiotics10060695
ISSN: 2079-6382
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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