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http://hdl.handle.net/2445/179068| Title: | Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor** |
| Author: | Morales, Paula Navarro Brugal, Gemma Gómez-Autet, Marc Redondo, Laura Fernández-Ruiz, Javier Pérez-Benito, Laura Cordomí, Arnau Pardo, Leonardo Franco Fernández, Rafael Jagerovic, Nadine |
| Keywords: | Receptors cel·lulars Proteïnes G Interacció cel·lular Cànnabis Cell receptors G Proteins Cell interaction Cannabis |
| Issue Date: | 9-Nov-2020 |
| Publisher: | Wiley-VCH |
| Abstract: | Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/chem.202003389 |
| It is part of: | Chemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842 |
| URI: | http://hdl.handle.net/2445/179068 |
| Related resource: | https://doi.org/10.1002/chem.202003389 |
| ISSN: | 0947-6539 |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 709677.pdf | 1.75 MB | Adobe PDF | View/Open |
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