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http://hdl.handle.net/2445/179255
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DC Field | Value | Language |
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dc.contributor.author | March Pons, David | - |
dc.contributor.author | Bianco, Valentino | - |
dc.contributor.author | Franzese, Giancarlo | - |
dc.date.accessioned | 2021-07-21T08:21:30Z | - |
dc.date.available | 2021-07-21T08:21:30Z | - |
dc.date.issued | 2021-01-03 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179255 | - |
dc.description.abstract | The behavior of proteins near interfaces is relevant for biological and medical purposes. Previous results in bulk show that, when the protein concentration increases, the proteins unfold and, at higher concentrations, aggregate. Here, we study how the presence of a hydrophobic surface affects this course of events. To this goal, we use a coarse-grained model of proteins and study by simulations their folding and aggregation near an ideal hydrophobic surface in an aqueous environment by changing parameters such as temperature and hydrophobic strength, related, e.g., to ions concentration. We show that the hydrophobic surface, as well as the other parameters, affect both the protein unfolding and aggregation. We discuss the interpretation of these results and define future lines for further analysis, with their possible implications in neurodegenerative diseases. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/polym13010156 | - |
dc.relation.ispartof | Polymers, 2021, vol. 13, num. 1, p. 156 | - |
dc.relation.uri | https://doi.org/10.3390/polym13010156 | - |
dc.rights | cc-by (c) March Pons, David et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Superfícies hidrofòbiques | - |
dc.subject.classification | Mètode de Montecarlo | - |
dc.subject.other | Proteins | - |
dc.subject.other | Hydrophobic surfaces | - |
dc.subject.other | Monte Carlo method | - |
dc.title | Protein Unfolding and Aggregation near a Hydrophobic Interface | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709398 | - |
dc.date.updated | 2021-07-21T08:21:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33401542 | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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File | Description | Size | Format | |
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709398.pdf | 742.34 kB | Adobe PDF | View/Open |
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