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http://hdl.handle.net/2445/179354| Title: | Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas |
| Author: | Subirós Funosas, Ramon Cheuk Lam Ho, Vivian Barth, Nicole D. Mendive Tapia, Lorena Pappalardo, Morena Barril Alonso, Xavier Ma, Ruoyu Zhang, Cheng-Bin Qian, Bin-Zhi Sintes Marcos, Miquel Ghashghaei, Ouldouz Lavilla Grífols, Rodolfo Vendrell, Marc |
| Keywords: | Pèptids Aminoàcids Apoptosi Peptides Amino acids Apoptosis |
| Issue Date: | 20-Jan-2020 |
| Publisher: | Royal Society of Chemistry |
| Abstract: | Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1039/C9SC05558D |
| It is part of: | Chemical Science, 2020, vol. 11, p. 1368-1374 |
| URI: | http://hdl.handle.net/2445/179354 |
| Related resource: | https://doi.org/10.1039/C9SC05558D |
| ISSN: | 2041-6520 |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| 695128.pdf | 1.9 MB | Adobe PDF | View/Open |
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