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http://hdl.handle.net/2445/181332
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DC Field | Value | Language |
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dc.contributor.author | Urpí Sardà, Mireia | - |
dc.contributor.author | Casas Rodríguez, Rosa M. | - |
dc.contributor.author | Sacanella Meseguer, Emilio | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.contributor.author | Llorach, Rafael | - |
dc.contributor.author | Garrabou Tornos, Glòria | - |
dc.contributor.author | Cardellach, Francesc | - |
dc.contributor.author | Sala Vila, Aleix | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Ruiz-Canela, Miguel | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Salas Salvadó, Jordi | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.date.accessioned | 2021-11-18T09:26:05Z | - |
dc.date.available | 2021-11-18T09:26:05Z | - |
dc.date.issued | 2021-07-22 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181332 | - |
dc.description.abstract | The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9080862 | - |
dc.relation.ispartof | Biomedicines, 2021 | - |
dc.relation.uri | https://doi.org/10.3390/biomedicines9080862 | - |
dc.rights | cc-by (c) Urpí Sardà, Mireia et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Nutrició | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Nutrition | - |
dc.title | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714022 | - |
dc.date.updated | 2021-11-18T09:26:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34440065 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Medicina) |
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714022.pdf | 1.04 MB | Adobe PDF | View/Open |
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