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Title: State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
Author: García-Torra, Victor
Cano Fernández, Amanda
Espina García, Marta
Ettcheto Arriola, Miren
Camins Espuny, Antoni
Barroso Fernández, Emma
Vazquez-Carrera, Manel
García López, María Luisa
Sánchez-López, E. (Elena)
Souto, Eliana B.
Keywords: Nanopartícules
Issue Date: 23-Aug-2021
Publisher: MDPI
Abstract: Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained. Keywords: metal nanoparticles; nanoparticles toxicity; reactive oxygen species; nanoparticles functionalization
Note: Reproducció del document publicat a:
It is part of: Toxics, 2021, vol. 9, num. 8, p. 195
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ISSN: 2305-6304
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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