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http://hdl.handle.net/2445/181865
Title: | Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines |
Author: | Fernández Delgado, Lucía Càmara, Jordi González Díaz, Aida Grau, Immaculada Shoji, Hisashi Tubau, Fe Martí, Sara Domínguez Luzón, Ma. Ángeles (María Ángeles) Carratalà, Jordi Yuste, Jose Ardanuy, Carmen |
Keywords: | Pneumònia Vacunes Pneumonia Vaccines |
Issue Date: | 28-Oct-2021 |
Publisher: | MDPI AG |
Abstract: | We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011-2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017-2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/microorganisms9112245 |
It is part of: | Microorganisms, 2021, vol 9, num 11 |
URI: | http://hdl.handle.net/2445/181865 |
Related resource: | https://doi.org/10.3390/microorganisms9112245 |
ISSN: | 2076-2607 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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