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http://hdl.handle.net/2445/182204
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DC Field | Value | Language |
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dc.contributor.author | Storniolo, Carolina Emilia | - |
dc.contributor.author | Pequera, M. | - |
dc.contributor.author | Company, F. | - |
dc.contributor.author | Moreno Aznárez, Juan José | - |
dc.date.accessioned | 2022-01-11T10:10:18Z | - |
dc.date.available | 2022-01-11T10:10:18Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182204 | - |
dc.description.abstract | 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is an unusual product of the cyclooxygenase pathway that is an endogenous ligand of the low-affinity receptor for leukotriene 4 (LTB4), BLT2. Recent findings suggested that BLT2 possibly plays an important role in the healing of intestinal lesions and the regulation of barrier function. Here, we studied the role of 12-HHT on intestinal epithelial cell growth and the paracellular permeability of intestinal epithelium using Caco-2 cell cultures as experimental model. Our results demonstrated that 12-HHT stimulates intestinal epithelial Caco-2 cell growth through 12-HHT-BLT2-p38-PKC axis and improves paracellular permeability in differentiated Caco-2 cell cultures through the regulation of tight junction elements such as myosin light chain phosphorylation through 12-HHT-BLT2-p38-PKC-MYPT1 axis. Thus, 12-HHT-BLT2 interaction can be involved in intestinal epithelial cell growth and consequently in the epithelium regeneration/repair processes, together with an interesting improvement on the paracellular permeability. These effects appoint that 12-HHT/BLT2 axis may be a suitable strategy for treating wound healing epithelium and barrier-disrupted intestinal processes. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.bcp.2021.114663 | - |
dc.relation.ispartof | Biochemical Pharmacology, 2021, vol. 190, p. 114663 | - |
dc.relation.uri | https://doi.org/10.1016/j.bcp.2021.114663 | - |
dc.rights | cc-by-nc-nd (c) Carolina Emilia Storniolo et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Icosanoides | - |
dc.subject.classification | Malalties inflamatòries intestinals | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Eicosanoids | - |
dc.subject.other | Inflammatory bowel diseases | - |
dc.title | 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) induces cell growth and improves barrier function through BLT2 interaction in intestinal epithelial Caco-2 cell cultures | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714643 | - |
dc.date.updated | 2022-01-11T10:10:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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714643.pdf | 2.21 MB | Adobe PDF | View/Open |
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