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http://hdl.handle.net/2445/182235
Title: | BCG Substrains Change Their Outermost Surface as a Function of Growth Media |
Author: | Guallar Garrido, Sandra Almiñana Rapún, Farners Campo Perez, Victor Torrents Serra, Eduard Luquin, Marina Julian, Esther |
Keywords: | Mycobacterium tuberculosis Química microbiològica Mycobacterium tuberculosis Microbiological chemistry |
Issue Date: | 30-Dec-2021 |
Abstract: | Mycobacterium bovis bacillus Calmette-Guérin (BCG) efficacy as an immunotherapy tool can be influenced by the genetic background or immune status of the treated population and by the BCG substrain used. BCG comprises several substrains with genetic differences that elicit diverse phenotypic characteristics. Moreover, modifications of phenotypic characteristics can be influenced by culture conditions. However, several culture media formulations are used worldwide to produce BCG. To elucidate the influence of growth conditions on BCG characteristics, five different substrains were grown on two culture media, and the lipidic profile and physico-chemical properties were evaluated. Our results show that each BCG substrain displays a variety of lipidic profiles on the outermost surface depending on the growth conditions. These modifications lead to a breadth of hydrophobicity patterns and a different ability to reduce neutral red dye within the same BCG substrain, suggesting the influence of BCG growth conditions on the interaction between BCG cells and host cells. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/vaccines10010040 |
It is part of: | Vaccines, 2021, vol. 10, num. 1 |
URI: | http://hdl.handle.net/2445/182235 |
Related resource: | https://doi.org/10.3390/vaccines10010040 |
ISSN: | 2076-393X |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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File | Description | Size | Format | |
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12537_6542827_vaccines-10-00040.pdf | 2.99 MB | Adobe PDF | View/Open |
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