Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182331
Title: | Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice |
Author: | Cabana Domínguez, Judit Martín-García, Elena Gallego-Roman, Ana Maldonado, Rafael, 1961- Fernàndez Castillo, Noèlia Cormand Rifà, Bru |
Keywords: | Drogoaddicció Genètica Cocaïna Drug addiction Genetics Cocaine |
Issue Date: | 11-Oct-2021 |
Publisher: | Nature Publishing Group |
Abstract: | Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers and in human dopaminergic neuron-like cells after an acute cocaine exposure. Here, we functionally tested the contribution of the PLCB1 gene to cocaine addictive properties using Plcb1+/- mice. First, we performed a general phenotypic characterization and found that Plcb1+/- mice showed normal behavior, although they had increased anxiety and impaired short-term memory. Subsequently, mice were trained for operant conditioning, self-administered cocaine for 10 days, and were tested for cocaine motivation. After extinction, we found a reduction in the cue-induced reinstatement of cocaine-seeking behavior in Plcb1+/- mice. After reinstatement, we identified transcriptomic alterations in the medial prefrontal cortex of Plcb1+/- mice, mostly related to pathways relevant to addiction like the dopaminergic synapse and long-term potentiation. To conclude, we found that heterozygous deletion of the Plcb1 gene decreases cue-induced reinstatement of cocaine-seeking, pointing at PLCB1 as a possible therapeutic target for preventing relapse and treating cocaine addiction. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41398-021-01396-6 |
It is part of: | Translational Psychiatry, 2021, vol. 11, num. 1, p. 521 |
URI: | http://hdl.handle.net/2445/182331 |
Related resource: | https://doi.org/10.1038/s41398-021-01396-6 |
ISSN: | 2158-3188 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE |
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