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Title: | Identification of recent tuberculosis exposure using QuantiFERON-TB Gold Plus, a multicenter study. |
Author: | Pérez Recio, Sandra Pallarès, Natàlia Grijota Camino, Maria D. Sánchez Montalvá, Adrián Barcia, Laura Campos Gutiérrez, Silvia Pomar, Virginia Rabuñal Rey, Ramón Balcells, Maria Elvira Gazel, Deniz Montiel, Natalia Vicente, Diego Goić-Barišić, Ivana Schön, Thomas Paues, Jakob Mareković, Ivana Cacho Calvo, Juana Barac, Aleksandra Goletti, Delia García Gasalla, Mercedes Barcala, José Maria Tórtola, María Teresa Anibarro, Luis Suárez Toste, Isabel Moga, Esther Gude Gonzalez, María J. Naves, Rodrigo Karslıgil, Tekin Martin Peñaranda, Tania Stevanovic, Goran Trigo, Matilde Rubio, Verónica Karaoğlan,, Ilkay Bayram, Nazan Alcaide, Fernando Tebé, Cristian Santín Cerezales, Miguel |
Keywords: | Proves funcionals (Medicina) Tuberculosi Function tests (Medicine) Tuberculosis |
Issue Date: | 10-Nov-2021 |
Publisher: | American Society for Microbiology Press, Washington DC, USA, |
Abstract: | We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value .0.6 IU ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of .0.6 IU ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 5.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of .0.6 IU ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection. |
Note: | Reproducció del document publicat a: https://doi.org/10.1128/Spectrum.00972-21 |
It is part of: | Microbiology Spectrum, 2021, vol. 9 , num. 3 |
URI: | http://hdl.handle.net/2445/182859 |
Related resource: | https://doi.org/10.1128/Spectrum.00972-21 |
ISSN: | 2165-0497 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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