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https://hdl.handle.net/2445/182935| Title: | A novel redox cycle diverts cells from oncogene-induced senescence into cancer |
| Author: | Maus, Mate Serrano Marugán, Manuel |
| Keywords: | Metabolisme cel·lular Oncogens Cell metabolism Oncogenes |
| Issue Date: | 21-Sep-2021 |
| Publisher: | Elsevier |
| Abstract: | Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Copyright © 2021 Elsevier Inc. All rights reserved. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.molcel.2021.08.023 |
| It is part of: | Molecular Cell, 2021, vol 81, num 18, 3672-3674 |
| URI: | https://hdl.handle.net/2445/182935 |
| Related resource: | https://doi.org/10.1016/j.molcel.2021.08.023 |
| ISSN: | 1097-4164 |
| Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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| 12541_6533990_maus__serrano_mol_cell_2021.pdf | 191.51 kB | Adobe PDF | View/Open |
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