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Title: A novel redox cycle diverts cells from oncogene-induced senescence into cancer
Author: Maus, Mate
Serrano, Manuel
Keywords: Metabolisme cel·lular
Cell metabolism
Issue Date: 21-Sep-2021
Publisher: Elsevier
Abstract: Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Copyright © 2021 Elsevier Inc. All rights reserved.
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It is part of: Molecular Cell, 2021, vol 81, num 18, 3672-3674
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ISSN: 1097-4164
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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