Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/182971
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorMartínez Balbás, Marian-
dc.contributor.authorIacobucci, Simona-
dc.contributor.otherUniversitat de Barcelona. Facultat de Biologia-
dc.date.accessioned2022-02-08T09:01:16Z-
dc.date.available2022-02-08T09:01:16Z-
dc.date.issued2021-03-18-
dc.identifier.urihttp://hdl.handle.net/2445/182971-
dc.description.abstract[eng] Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To do that, we determined the following objectives: 1. To investigate the role of PHF8 histone demethylase during astrocytes differentiation. • Analyse the PHF8-mediated transcriptional profile in astrocytes. • Determine the chromatin bound regions of PHF8 in astrocytes. • Elucidate astrocytes phenotype upon PHF8 depletion. • Examine astrocytic PHF8 function during synaptogenesis. • Determine the molecular mechanism responsible for the PHF8- associated phenotype in astrocytes. 2. To elucidate the function of PHF8 in neural stem cells. • Examine neural stem cells phenotype upon PHF8 depletion. • Determine the PHF8-mediated transcriptional profile in neural stem cells. • Analyse the metabolic impact of PHF8 depletion.ca
dc.format.extent159 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengca
dc.publisherUniversitat de Barcelona-
dc.rights(c) Iacobucci, Simona, 2022-
dc.sourceTesis Doctorals - Facultat - Biologia-
dc.subject.classificationBiologia molecular-
dc.subject.classificationGenòmica-
dc.subject.classificationCèl·lules mare-
dc.subject.classificationNeurologia-
dc.subject.classificationAstròcits-
dc.subject.classificationHistones-
dc.subject.otherMolecular biology-
dc.subject.otherGenomics-
dc.subject.otherStem cells-
dc.subject.otherNeurology-
dc.subject.otherAstrocytes-
dc.titleFunction of the histone demethylase PHF8 in neural progenitor cells and glial differentiationca
dc.typeinfo:eu-repo/semantics/doctoralThesisca
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.identifier.tdxhttp://hdl.handle.net/10803/673438-
Appears in Collections:Tesis Doctorals - Facultat - Biologia

Files in This Item:
File Description SizeFormat 
SIMONA IACOBUCCI_PhD_THESIS.pdf2.16 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.