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Title: Evaluating the impact of programmatic mass drug administration for malaria in Zambia using routine incidence data.
Author: Fraser, Maya
Miller, John M.
Silumbe, Kafula
Hainsworth, Michael
Mudenda, Mutinta
Hamainza, Busiko
Moonga, Hawela
Chizema Kawesha, Elizabeth
Mercer, Laina D.
Bennett, Adam
Schneider, Kammerle
Slater, Hannah C.
Eisele, Thomas P.
Guinovart, Caterina
Keywords: Malària
Política sanitària
Medical policy
Issue Date: 2021
Publisher: Oxford University Press
Abstract: BACKGROUND NlmCategory: BACKGROUND content: In 2016, the Zambian National Malaria Elimination Centre started programmatic mass drug administration (pMDA) campaigns with dihydroartemisinin-piperaquine as a malaria elimination tool in Southern Province. Two rounds were administered, two months apart (coverage 70% and 57% respectively). We evaluated the impact of one year of pMDA on malaria incidence using routine data. - Label: METHODS NlmCategory: METHODS content: We conducted an interrupted time series with comparison group analysis on monthly incidence data collected at the health facility catchment area (HFCA) level, with a negative binomial model using generalized estimating equations. pMDA was conducted in HFCAs with greater than 50 cases/1,000 people/year. Ten HFCAs with incidence rates marginally above this threshold (pMDA group) were compared to 20 HFCAs marginally below (comparison group). - Label: RESULTS NlmCategory: RESULTS content: "The pMDA HFCAs saw a 46% greater decrease in incidence at the time of intervention than the comparison areas (incidence rate ratio: 0.536 [0.337-0.852]); however, incidence increased toward the end of the season. No HFCAs saw a transmission interruption." - Label: CONCLUSION NlmCategory: CONCLUSIONS content: pMDA, implemented during one year with imperfect coverage in low transmission areas with sub-optimal vector control coverage, significantly reduced incidence. However, elimination will require additional tools. Routine data are important resources for programmatic impact evaluations and should be considered for future analyses.
Note: Reproducció del document publicat a: 10.1093/infdis/jiaa434
It is part of: Journal of Infectious Diseases, 2021
Related resource: 10.1093/infdis/jiaa434
ISSN: 0022-1899
Appears in Collections:Articles publicats en revistes (ISGlobal)

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