Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/184033
Title: | Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice |
Author: | Alegre-Zurano, Laia López-Arnau, Raúl Luján, Miguel Á. Camarasa García, Jordi Valverde, O. |
Keywords: | Cànnabis Ansietat Farmacologia Cannabis Anxiety Pharmacology |
Issue Date: | 2-Aug-2021 |
Publisher: | MDPI |
Abstract: | : 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the "bath salts". Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigms. In addition, we assessed the effects of the co-administration of CBD and MDPV (3 and 4 mg/kg) on anxietylike behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Furthermore, CBD exerted anxiolytic-like effects, exclusively in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice varies depending on the requirements of the learning task, resulting in a complex response. Therefore, further research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22158304 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 2021, num. 22, p. 8304-8317 |
URI: | http://hdl.handle.net/2445/184033 |
Related resource: | https://doi.org/10.3390/ijms22158304 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
716586.pdf | 1.82 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License