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http://hdl.handle.net/2445/184118
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DC Field | Value | Language |
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dc.contributor.author | Vilela, Diana | - |
dc.contributor.author | Blanco-Cabra, Núria | - |
dc.contributor.author | Eguskiza, Ander | - |
dc.contributor.author | Hortelao, Ana C. | - |
dc.contributor.author | Torrents Serra, Eduard | - |
dc.contributor.author | Sánchez, Samuel | - |
dc.date.accessioned | 2022-03-15T11:00:49Z | - |
dc.date.available | 2022-03-15T11:00:49Z | - |
dc.date.issued | 2021-03-26 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184118 | - |
dc.description.abstract | The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzyme- based nanomotors for the treatment of bacterial urinary-tract infections. We develop nanomotors consisting of mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or urease and lysozyme (M- MSNPs), and use them against nonpathogenic planktonic Escherichia coli. U-MSNPs exhibited the highest bactericidal activity due to biocatalysis of urea into NaHCO3 and NH3, which also propels U-MSNPs. In addition, U-MSNPs in concentrations above 200 μg/mL were capable of successfully reducing 60% of the biofilm biomass of a uropathogenic E. coli strain. This study thus provides a proof-of-concept, demonstrating that enzyme-based nanomotors are capable of fighting infectious diseases. This approach could potentially be extended to other kinds of diseases by selecting appropriate biomolecules. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1021/acsami.1c00986 | - |
dc.relation.ispartof | ACS Applied Materials & Interfaces, 2021, vol. 13, num. 13, p. 14964-14973 | - |
dc.relation.uri | https://doi.org/10.1021/acsami.1c00986 | - |
dc.rights | cc by (c) Vilela, Diana et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Infeccions per escheríchia coli | - |
dc.subject.classification | Biofilms | - |
dc.subject.classification | Nanotecnologia | - |
dc.subject.other | Escherichia coli infections | - |
dc.subject.other | Biofilms | - |
dc.subject.other | Nanotechnology | - |
dc.title | Drug-free Enzyme-based bactericidal nanomotors against pathogenic bacteria | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 720712 | - |
dc.date.updated | 2022-03-15T11:00:49Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/866348/EU//i-NANOSWARMS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/712754/EU//BEST | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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720712.pdf | 6.34 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License