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Title: The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
Author: Molina García, Mariola
Fraguas, David
Del Rey Mejias, Angel
Mezquida Mateos, Gisela
Sánchez-Torres, Ana M.
Amoretti Guadall, Silvia
Lobo, Antonio
González-Pinto, Ana
Andreu-Bernabeu, Álvaro
Corripio, Iluminada
Vieta i Pascual, Eduard, 1963-
Baeza, Inmaculada, 1970-
Mané Santacana, Anna
Cuesta, Manuel J.
Serna Gómez, Elena de la
Payá, Beatriz
Zorrilla, Iñaki
Arango, Celso
Bernardo Arroyo, Miquel
Rapado-Castro, Marta
Parellada, Mara
PEPs Group
Keywords: Psicosi
Pronòstic mèdic
Issue Date: 2-Jun-2021
Publisher: MDPI
Abstract: Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.
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It is part of: Journal of Clinical Medicine, 2021, vol. 10, num. 11, p. 2474
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ISSN: 2077-0383
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Medicina)

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