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Title: | HACEK infective endocarditis: epidemiology, clinical features outcome: A case-control study |
Author: | Ambrosioni, Juan Martínez García, Clara Llopis, Jaume García de la Mària, Cristina Hernández-Meneses, Marta Tellez, Adrian Falces Salvador, Carles Almela, Manel Vidal, Bàrbara Sandoval, Elena Fuster, David Quintana, Eduard Tolosana, José M. (José María) Marco, Francesc Moreno, Asunción Miró, José M. The Hospital Clinic Infective Endocarditis Investigators |
Keywords: | Endocarditis Epidemiologia Medicina clínica Endocarditis Epidemiology Clinical medicine |
Issue Date: | 25-Aug-2018 |
Publisher: | Elsevier B.V. |
Abstract: | OBJECTIVES: The study aimed to describe the epidemiology, microbiological and clinical features of a population sample of 17 patients with HACEK-IE and to compare them with matched control patients with IE caused by Viridans group Streptococci (VGS-IE). METHODS: Description of definite (14; 82.2%) and possible (3; 17.6%) HACEK-IE included in the 'Infective Endocarditis Hospital Clínic of Barcelona' (IE-HCB) database between 1979 and 2016. Furthermore, a retrospective case-control analysis was performed, matching each case to three VGS-IE controls registered in the same database during the same period of time. RESULTS: Seventeen out of 1,209 IE cases (1.3%, 95%CI 0.69-1.91) were due to HACEK group. The most frequent isolated HACEK species were Aggregatibacter spp (11; 64.7%). Intracardiac vegetations were present in 70.6% of cases. Left heart failure (LHF) was present in 29.4% of cases. Ten patients (58.8%) required in-hospital surgery and none died during hospitalization. In the case-control analysis, there was a trend toward larger vegetations in the HACEK-IE group (median (IRQ) size=11.5 (10.0-20.0) mm vs 9.0 (7.0-13.0) mm; p=0.068). Clinical manifestations, echocardiographic findings, LHF rate, systemic emboli and other complications were all comparable (p >0.05). In-hospital surgery and mortality were similar for both groups. One-year mortality was lower for HACEK-IE (1/17 vs. to 6/48, p=0.006). CONCLUSIONS: HACEK-IE represented 1.3% of all IE cases. Clinical features and outcome were comparable with the VGS-IE control group. Despite the trend tow |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2018.08.013 |
It is part of: | International Journal of Infectious Diseases, 2018, vol. 76, p. 120-125 |
URI: | http://hdl.handle.net/2445/184345 |
Related resource: | https://doi.org/10.1016/j.ijid.2018.08.013 |
ISSN: | 1201-9712 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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