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Title: | Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19. |
Author: | Meira, Fernanda Moreno García, Estela Linares, Laura Macaya, Irene Tomé, Adrià Hernández-Meneses, Marta Albiach, Laia Morata, Laura Letona Giménez, Laura Bodro, Marta Cózar Llistó, Alberto Cardozo Espinola, Celia Chumbita, Mariana Pitart, Cristina Ambrosioni, Juan Rico, Verónica Agüero, Daiana Puerta-Alcalde, Pedro García Pouton, Nicole Marco, Francesc Garcia Vidal, Carolina Soriano Viladomiu, Alex Martínez, José Antonio |
Keywords: | COVID-19 SARS-CoV-2 Infeccions nosocomials COVID-19 SARS-CoV-2 Nosocomial infections |
Issue Date: | 11-Jun-2021 |
Publisher: | Springer Nature |
Abstract: | The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). METHODS: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case. RESULTS: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001). CONCLUSIONS: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s40121-021-00477-9 |
It is part of: | Infectious Diseases and Therapy, 2021, vol. 10, num. 3, p. 1407-1418 |
URI: | http://hdl.handle.net/2445/184472 |
Related resource: | https://doi.org/10.1007/s40121-021-00477-9 |
ISSN: | 2193-8229 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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