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Title: Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19.
Author: Meira, Fernanda
Moreno García, Estela
Linares, Laura
Macaya, Irene
Tomé, Adrià
Hernández-Meneses, Marta
Albiach, Laia
Morata, Laura
Letona Giménez, Laura
Bodro, Marta
Cózar Llistó, Alberto
Cardozo Espinola, Celia
Chumbita, Mariana
Pitart, Cristina
Ambrosioni, Juan
Rico, Verónica
Agüero, Daiana
Puerta Alcalde, Pedro
Garcia-Pouton, Nicole
Marco, Francesc
Garcia Vidal, Carolina
Soriano Viladomiu, Alex
Martínez, José Antonio
Keywords: COVID-19
Infeccions nosocomials
Nosocomial infections
Issue Date: 11-Jun-2021
Publisher: Springer Nature
Abstract: The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). METHODS: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case. RESULTS: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001). CONCLUSIONS: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk.
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It is part of: Infectious Diseases and Therapy, 2021, vol. 10, num. 3, p. 1407-1418
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ISSN: 2193-8229
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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