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http://hdl.handle.net/2445/184630
Title: | Circulating cell-free DNA in breast cancer: searching for hidden information towards precision medicine |
Author: | Panagopoulou, Maria Esteller, Manel Chatzaki, Ekaterini |
Keywords: | Càncer de mama Pronòstic mèdic ADN Biòpsia Marcadors bioquímics Breast cancer Prognosis DNA Biopsy Biochemical markers |
Issue Date: | 10-Feb-2021 |
Publisher: | MDPI |
Abstract: | Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. Lately, research is focusing on circulating biomarkers as minimally invasive choices for diagnosis, prognosis and treatment monitoring. Circulating cell-free DNA (ccfDNA) is a promising liquid biopsy biomaterial of great potential as it is thought to mirror the tumor's lifespan; however, its clinical exploitation is burdened mainly by gaps in knowledge of its biology and specific characteristics. The current review aims to gather latest findings about the nature of ccfDNA and its multiple molecular and biological characteristics in breast cancer, covering basic and translational research and giving insights about its validity in a clinical setting. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers13040728 |
It is part of: | Cancers, 2021, vol. 13, num. 4, p. 728 |
URI: | http://hdl.handle.net/2445/184630 |
Related resource: | https://doi.org/10.3390/cancers13040728 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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