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Title: Circulating cell-free DNA in breast cancer: searching for hidden information towards precision medicine
Author: Panagopoulou, Maria
Esteller, Manel
Chatzaki, Ekaterini
Keywords: Càncer de mama
Pronòstic mèdic
Marcadors bioquímics
Breast cancer
Biochemical markers
Issue Date: 10-Feb-2021
Publisher: MDPI
Abstract: Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. Lately, research is focusing on circulating biomarkers as minimally invasive choices for diagnosis, prognosis and treatment monitoring. Circulating cell-free DNA (ccfDNA) is a promising liquid biopsy biomaterial of great potential as it is thought to mirror the tumor's lifespan; however, its clinical exploitation is burdened mainly by gaps in knowledge of its biology and specific characteristics. The current review aims to gather latest findings about the nature of ccfDNA and its multiple molecular and biological characteristics in breast cancer, covering basic and translational research and giving insights about its validity in a clinical setting.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2021, vol. 13, num. 4, p. 728
Related resource:
ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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